Anti-B27 antibody (ab168120)
Key features and details
- Mouse polyclonal to B27
- Suitable for: WB
- Reacts with: Human
- Isotype: IgG
Overview
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Product name
Anti-B27 antibody -
Description
Mouse polyclonal to B27 -
Host species
Mouse -
Tested applications
Suitable for: WBmore details -
Species reactivity
Reacts with: Human
Predicted to work with: Chimpanzee -
Immunogen
Recombinant full length protein within Human B27 aa 1-200. The exact immunogen sequence used to generate this antibody is proprietary information. If additional detail on the immunogen is needed to determine the suitability of the antibody for your needs, please contact our Scientific Support team to discuss your requirements.
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Positive control
- B27 transfected 293T cell lysate
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General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle. -
Storage buffer
pH: 7.4
Constituent: 99% PBS -
Concentration information loading...
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Purity
Protein A purified -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab168120 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
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WB | (1) |
Use a concentration of 1 µg/ml. Predicted molecular weight: 19 kDa.
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Notes |
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WB
Use a concentration of 1 µg/ml. Predicted molecular weight: 19 kDa. |
Target
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Function
Required for MC2R expression in certain cell types, suggesting that it is involved in the processing, trafficking or function of MC2R. May be involved in the intracellular trafficking pathways in adipocyte cells. -
Tissue specificity
Expressed in adrenal cortex, testis, breast, thyroid, lymph node, ovary and fat. Expressed in adipose tissues. -
Involvement in disease
Defects in MRAP are the cause of glucocorticoid deficiency type 2 (GCCD2) [MIM:607398]; also known as familial glucocorticoid deficiency type 2 (FGD2). GCCD2 is an autosomal recessive disorder due to congenital insensitivity or resistance to adrenocorticotropin (ACTH). It is characterized by progressive primary adrenal insufficiency, without mineralocorticoid deficiency. -
Cellular localization
Cytoplasm > perinuclear region. Cytoplasm. Cell membrane. Endoplasmic reticulum. Concentrated at the perinuclear membrane region. Upon insulin stimulation, it is redistributed into spotty structures throughout the cytoplasm (By similarity). Localizes both to plasma membrane and endoplasmic reticulum. - Information by UniProt
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Database links
- Entrez Gene: 746245 Chimpanzee
- Entrez Gene: 56246 Human
- Omim: 609196 Human
- SwissProt: Q68UT4 Chimpanzee
- SwissProt: Q8TCY5 Human
- Unigene: 584940 Human
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Alternative names
- B27 antibody
- C21orf61 antibody
- FALP antibody
see all
Images
Datasheets and documents
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Datasheet download
References (1)
ab168120 has been referenced in 1 publication.
- Nanba K et al. H295R expression of melanocortin 2 receptor accessory protein results in ACTH responsiveness. J Mol Endocrinol 56:69-76 (2016). PubMed: 26576642