Product nameAnti-B3GAT1 antibody [HNK-1/ Leu-7]
See all CD57 primary antibodies
DescriptionMouse Monoclonal [HNK-1/ Leu-7] to B3GAT1
Specificityab187274 marks a subset of lymphocytes known as natural killer (NK) cells. Follicular center cell lymphomas often contain many NK cells within the neoplastic follicles. ab187274 also stains neuroendocrine cells and their derived tumors, including carcinoid tumor and medulloblastoma. ab187274 can also be useful in separating type B3 thymoma from thymic carcinoma when combined with a panel that includes antibodies against GLUT1, CD5, and CEA.
Tested applicationsSuitable for: ICC/IF, Flow Cyt, WB, IHC-Pmore details
Species reactivityReacts with: Human
Does not react with: Rat
Tissue, cells or virus corresponding to Human CD57. Human peripheral blood mononuclear cells.
- Lymph node, Tonsil
Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
Storage bufferPreservative: 0.05% Sodium azide
Concentration information loading...
Clone numberHNK-1/ Leu-7
Light chain typekappa
Our Abpromise guarantee covers the use of ab187274 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|ICC/IF||1/50 - 1/100.|
|Flow Cyt||Use 5-10µl for 106 cells.
ab18400 - Mouse monoclonal IgM, is suitable for use as an isotype control with this antibody.
|WB||1/100 - 1/200.|
|IHC-P||1/50 - 1/100.|
RelevanceCD57 is a carbohydrate epitope that contains a sulfoglucuronyl residue in several adhesion molecules of the nervous system. Is is created by Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1 (B3GAT1) The CD57 antigen is present on subsets of T cells and natural killer cells.
- HKN1 antibody
- LEU7 antibody
This product has been referenced in:
- Ng SY et al. Targetable vulnerabilities in T- and NK-cell lymphomas identified through preclinical models. Nat Commun 9:2024 (2018). Read more (PubMed: 29789628) »
- Yu P et al. Comparative pathology of rhesus macaque and common marmoset animal models with Middle East respiratory syndrome coronavirus. PLoS One 12:e0172093 (2017). Read more (PubMed: 28234937) »