Overview

  • Product name

  • Description

    Goat polyclonal to B7H4
  • Host species

    Goat
  • Tested applications

    Suitable for: WBmore details
  • Species reactivity

    Reacts with: Human
    Predicted to work with: Mouse, Rat, Cow, Dog
  • Immunogen

    Synthetic peptide:

    C-PEVNVDYNASSET

    with a Cysteine residue linker,corresponding to internal sequence amino acids 153-165 of Human B7H4 (NP_078902.2).

  • Positive control

    • Human Spleen lysate.

Properties

Applications

Our Abpromise guarantee covers the use of ab130151 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 0.1 - 0.3 µg/ml. Detects a band of approximately 28 kDa (predicted molecular weight: 31 kDa).

Target

  • Function

    Negatively regulates T-cell-mediated immune response by inhibiting T-cell activation, proliferation, cytokine production and development of cytotoxicity. When expressed on the cell surface of tumor macrophages, plays an important role, together with regulatory T-cells (Treg), in the suppression of tumor-associated antigen-specific T-cell immunity. Involved in promoting epithelial cell transformation.
  • Tissue specificity

    Overexpressed in breast, ovarian, endometrial, renal cell (RCC) and non-small-cell lung cancers (NSCLC). Expressed on activated T- and B-cells, monocytes and dendritic cells, but not expressed in most normal tissues (at protein level). Widely expressed, including in kidney, liver, lung, ovary, placenta, spleen and testis.
  • Sequence similarities

    Belongs to the immunoglobulin superfamily. BTN/MOG family.
    Contains 2 Ig-like V-type (immunoglobulin-like) domains.
  • Post-translational
    modifications

    N-glycosylated.
  • Cellular localization

    Cell membrane. Expressed at the cell surface. A soluble form has also been detected.
  • Information by UniProt
  • Database links

  • Alternative names

    • B7 family member, H4 antibody
    • B7 H4 antibody
    • B7 homolog 4 antibody
    • B7 superfamily member 1 antibody
    • B7 superfamily, member 1 antibody
    • B7-H4 antibody
    • B7h.5 antibody
    • B7h4 antibody
    • B7S1 antibody
    • B7x antibody
    • BC032925 antibody
    • Immune costimulatory protein B7-H4 antibody
    • Immune costimulatory protein B7H4 antibody
    • MGC41287 antibody
    • PRO1291 antibody
    • Protein B7S1 antibody
    • RP11 229A19.4 antibody
    • T cell costimulatory molecule B7x antibody
    • T-cell costimulatory molecule B7x antibody
    • V set domain-containing T cell activation inhibitor 1 antibody
    • V-set domain-containing T-cell activation inhibitor 1 antibody
    • VCTN1 antibody
    • Vtcn1 antibody
    • VTCN1_HUMAN antibody
    see all

Images

  • Anti-B7H4 antibody (ab130151) at 0.2 µg/ml + Human Spleen lysate (in RIPA buffer) at 35 µg

    Developed using the ECL technique.

    Predicted band size: 31 kDa



    Primary incubation was 1 hour.

References

This product has been referenced in:

  • Zhao X  et al. Aberrant expression of B7-H4 correlates with poor prognosis and suppresses tumor-infiltration of CD8+ T lymphocytes in human cholangiocarcinoma. Oncol Rep 36:419-27 (2016). Read more (PubMed: 27177355) »
See 1 Publication for this product

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