Overview

  • Product name
  • Description
    Rabbit polyclonal to B7H4
  • Host species
    Rabbit
  • Specificity
    At least three isoforms of B7H4 are known to exist. ab176146 will only detect the largest isoform of B7H4.
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Mouse, Human
  • Immunogen

    Synthetic peptide corresponding to Human B7H4 (internal sequence). (18 amino acid peptide).
    Database link: NP_078902

  • Positive control
    • EL4 cell lysate.

Properties

Applications

Our Abpromise guarantee covers the use of ab176146 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 - 2 µg/ml. Predicted molecular weight: 31 kDa.

Target

  • Function
    Negatively regulates T-cell-mediated immune response by inhibiting T-cell activation, proliferation, cytokine production and development of cytotoxicity. When expressed on the cell surface of tumor macrophages, plays an important role, together with regulatory T-cells (Treg), in the suppression of tumor-associated antigen-specific T-cell immunity. Involved in promoting epithelial cell transformation.
  • Tissue specificity
    Overexpressed in breast, ovarian, endometrial, renal cell (RCC) and non-small-cell lung cancers (NSCLC). Expressed on activated T- and B-cells, monocytes and dendritic cells, but not expressed in most normal tissues (at protein level). Widely expressed, including in kidney, liver, lung, ovary, placenta, spleen and testis.
  • Sequence similarities
    Belongs to the immunoglobulin superfamily. BTN/MOG family.
    Contains 2 Ig-like V-type (immunoglobulin-like) domains.
  • Post-translational
    modifications
    N-glycosylated.
  • Cellular localization
    Cell membrane. Expressed at the cell surface. A soluble form has also been detected.
  • Information by UniProt
  • Database links
  • Alternative names
    • B7 family member, H4 antibody
    • B7 H4 antibody
    • B7 homolog 4 antibody
    • B7 superfamily member 1 antibody
    • B7 superfamily, member 1 antibody
    • B7-H4 antibody
    • B7h.5 antibody
    • B7h4 antibody
    • B7S1 antibody
    • B7x antibody
    • BC032925 antibody
    • Immune costimulatory protein B7-H4 antibody
    • Immune costimulatory protein B7H4 antibody
    • MGC41287 antibody
    • PRO1291 antibody
    • Protein B7S1 antibody
    • RP11 229A19.4 antibody
    • T cell costimulatory molecule B7x antibody
    • T-cell costimulatory molecule B7x antibody
    • V set domain-containing T cell activation inhibitor 1 antibody
    • V-set domain-containing T-cell activation inhibitor 1 antibody
    • VCTN1 antibody
    • Vtcn1 antibody
    • VTCN1_HUMAN antibody
    see all

Images

  • Anti-B7H4 antibody (ab176146) at 1 µg/ml + EL4 cell lysate at 15 µg

    Predicted band size: 31 kDa

References

This product has been referenced in:
  • Cui L  et al. Downregulation of B7-H4 in the MHCC97-H hepatocellular carcinoma cell line by arsenic trioxide. Mol Med Rep 13:2032-8 (2016). WB ; Human . Read more (PubMed: 26781180) »
See 1 Publication for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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