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ab2077 has been referenced in 45 publications.

  • Wu Y  et al. Microglia and amyloid precursor protein coordinate control of transient Candida cerebritis with memory deficits. Nat Commun 10:58 (2019). PubMed: 30610193
  • Satomoto M  et al. Sevoflurane preconditioning ameliorates lipopolysaccharide-induced cognitive impairment in mice. Exp Anim 67:193-200 (2018). PubMed: 29187700
  • Wang Q  et al. Resistant starch prevents tumorigenesis of dimethylhydrazine-induced colon tumors via regulation of an ER stress-mediated mitochondrial apoptosis pathway. Int J Mol Med 41:1887-1898 (2018). PubMed: 29393371
  • Tang Y  et al. Estrogen-related receptor alpha is involved in Alzheimer's disease-like pathology. Exp Neurol 305:89-96 (2018). PubMed: 29641978
  • Hsu WH  et al. The neuronal protection of a zinc-binding protein isolated from oyster. Food Chem Toxicol 114:61-68 (2018). PubMed: 29432843
  • Zhang F  et al. Impacts of Acute Hypoxia on Alzheimer's Disease-Like Pathologies in APPswe/PS1dE9 Mice and Their Wild Type Littermates. Front Neurosci 12:314 (2018). PubMed: 29867325
  • Min Z  et al. Cosmosiin Increases ADAM10 Expression via Mechanisms Involving 5'UTR and PI3K Signaling. Front Mol Neurosci 11:198 (2018). PubMed: 29942252
  • Park TS  et al. Humulus japonicus inhibits the progression of Alzheimer's disease in a APP/PS1 transgenic mouse model. Int J Mol Med 39:21-30 (2017). PubMed: 28004107
  • Grimm MOW  et al. Vitamin D and Its Analogues Decrease Amyloid-ß (Aß) Formation and Increase Aß-Degradation. Int J Mol Sci 18:N/A (2017). PubMed: 29257109
  • An F  et al. MiR-124 acts as a target for Alzheimer's disease by regulating BACE1. Oncotarget 8:114065-114071 (2017). PubMed: 29371969
  • Durairajan SSK  et al. A modified formulation of Huanglian-Jie-Du-Tang reduces memory impairments and ß-amyloid plaques in a triple transgenic mouse model of Alzheimer's disease. Sci Rep 7:6238 (2017). WB . PubMed: 28740171
  • Pawlosky RJ  et al. Effects of a dietary ketone ester on hippocampal glycolytic and tricarboxylic acid cycle intermediates and amino acids in a 3xTgAD mouse model of Alzheimer's disease. J Neurochem 141:195-207 (2017). PubMed: 28099989
  • Huang JZ  et al. Catalpol preserves neural function and attenuates the pathology of Alzheimer's disease in mice. Mol Med Rep 13:491-6 (2016). PubMed: 26531891
  • Devraj K  et al. BACE-1 is expressed in the blood-brain barrier endothelium and is upregulated in a murine model of Alzheimer's disease. J Cereb Blood Flow Metab 36:1281-94 (2016). PubMed: 26661166
  • Bergkvist L  et al. AßPP processing results in greater toxicity per amount of Aß1-42 than individually expressed and secreted Aß1-42 in Drosophila melanogaster. Biol Open 5:1030-9 (2016). PubMed: 27387531
  • Yan X  et al. Ginsenoside Rd. promotes non-amyloidogenic pathway of amyloid precursor protein processing by regulating phosphorylation of estrogen receptor alpha. Life Sci N/A:N/A (2016). PubMed: 27825720
  • Hung CO & Coleman MP KIF1A mediates axonal transport of BACE1 and identification of independently moving cargoes in living SCG neurons. Traffic 17:1155-1167 (2016). ICC/IF ; Mouse . PubMed: 27484852
  • Wang X  et al. Effects and possible mechanisms of action of acacetin on the behavior and eye morphology of Drosophila models of Alzheimer's disease. Sci Rep 5:16127 (2015). WB ; Drosophila melanogaster . PubMed: 26530776
  • Che H  et al. Expression of amyloid-associated miRNAs in both the forebrain cortex and hippocampus of middle-aged rat. Cell Physiol Biochem 33:11-22 (2014). PubMed: 24401368
  • Guo LY  et al. Iron increases APP translation and amyloid-beta production in the retina. Exp Eye Res 129:31-7 (2014). WB ; Human . PubMed: 25456519
  • Xu Z  et al. Age-dependent postoperative cognitive impairment and Alzheimer-related neuropathology in mice. Sci Rep 4:3766 (2014). WB ; Mouse . PubMed: 24441878
  • Shin JW  et al. a-Asarone Ameliorates Memory Deficit in Lipopolysaccharide-Treated Mice via Suppression of Pro-Inflammatory Cytokines and Microglial Activation. Biomol Ther (Seoul) 22:17-26 (2014). WB . PubMed: 24596617
  • Zhang Y  et al. Chronic treatment with anesthetic propofol attenuates ß-amyloid protein levels in brain tissues of aged mice. Transl Neurodegener 3:8 (2014). WB ; Mouse . PubMed: 24725331
  • Orejana L  et al. Sildenafil Decreases BACE1 and Cathepsin B Levels and Reduces APP Amyloidogenic Processing in the SAMP8 Mouse. J Gerontol A Biol Sci Med Sci N/A:N/A (2014). Mouse . PubMed: 25063079
  • Ma T  et al. Suppression of eIF2a kinases alleviates Alzheimer's disease-related plasticity and memory deficits. Nat Neurosci 16:1299-305 (2013). WB ; Mouse . PubMed: 23933749
  • Ai J  et al. MicroRNA-195 protects against dementia induced by chronic brain hypoperfusion via its anti-amyloidogenic effect in rats. J Neurosci 33:3989-4001 (2013). WB, ICC/IF ; Rat . PubMed: 23447608
  • Ding Y  et al. Biochemical Inhibition of the Acetyltransferases ATase1 and ATase2 Reduces ß-Secretase (BACE1) Levels and Aß Generation. J Biol Chem 287:8424-33 (2012). WB . PubMed: 22267734
  • Yang SG  et al. A peptide binding to the ß-site of APP improves spatial memory and attenuates Aß burden in Alzheimer's disease transgenic mice. PLoS One 7:e48540 (2012). WB ; Mouse . PubMed: 23133641
  • Deane R  et al. A multimodal RAGE-specific inhibitor reduces amyloid ß-mediated brain disorder in a mouse model of Alzheimer disease. J Clin Invest 122:1377-92 (2012). PubMed: 22406537
  • Maarouf CL  et al. Alzheimer's disease and non-demented high pathology control nonagenarians: comparing and contrasting the biochemistry of cognitively successful aging. PLoS One 6:e27291 (2011). WB ; Human . PubMed: 22087282
  • Zhao Y  et al. Docosahexaenoic acid-derived neuroprotectin D1 induces neuronal survival via secretase- and PPAR?-mediated mechanisms in Alzheimer's disease models. PLoS One 6:e15816 (2011). WB ; Mouse . PubMed: 21246057
  • Chakraborty R  et al. Characterization of a Drosophila Alzheimer's disease model: pharmacological rescue of cognitive defects. PLoS One 6:e20799 (2011). WB ; Human, Drosophila melanogaster . PubMed: 21673973
  • Wozniak MA  et al. Antivirals reduce the formation of key Alzheimer's disease molecules in cell cultures acutely infected with herpes simplex virus type 1. PLoS One 6:e25152 (2011). ICC ; African green monkey . PubMed: 22003387
  • Jonas MC  et al. AT-1 is the ER membrane acetyl-CoA transporter and is essential for cell viability. J Cell Sci 123:3378-88 (2010). WB ; Chinese hamster . PubMed: 20826464
  • Liu M  et al. PCSK9 is not involved in the degradation of LDL receptors and BACE1 in the adult mouse brain. J Lipid Res 51:2611-8 (2010). WB . PubMed: 20453200
  • Ko MH & Puglielli L Two endoplasmic reticulum (ER)/ER Golgi intermediate compartment-based lysine acetyltransferases post-translationally regulate BACE1 levels. J Biol Chem 284:2482-92 (2009). WB . PubMed: 19011241
  • Kitazume S  et al. Molecular insights into beta-galactoside alpha2,6-sialyltransferase secretion in vivo. Glycobiology 19:479-87 (2009). WB ; Human . PubMed: 19150807
  • Porayette P  et al. Differential processing of amyloid-beta precursor protein directs human embryonic stem cell proliferation and differentiation into neuronal precursor cells. J Biol Chem 284:23806-17 (2009). WB ; Human . PubMed: 19542221
  • Dong Y  et al. The common inhalational anesthetic sevoflurane induces apoptosis and increases beta-amyloid protein levels. Arch Neurol 66:620-31 (2009). PubMed: 19433662
  • Zhang B  et al. The Inhalation Anesthetic Desflurane Induces Caspase Activation and Increases Amyloid {beta}-Protein Levels under Hypoxic Conditions. J Biol Chem 283:11866-75 (2008). WB ; Human . PubMed: 18326038
  • Woodard-Grice AV  et al. Proteolytic shedding of ST6Gal-I by BACE1 regulates the glycosylation and function of alpha4beta1 integrins. J Biol Chem 283:26364-73 (2008). WB ; Human . PubMed: 18650447
  • Xie Z  et al. RNA interference silencing of the adaptor molecules ShcC and Fe65 differentially affect amyloid precursor protein processing and Abeta generation. J Biol Chem 282:4318-25 (2007). PubMed: 17170108
  • Xie Z  et al. The inhalation anesthetic isoflurane induces a vicious cycle of apoptosis and amyloid beta-protein accumulation. J Neurosci 27:1247-54 (2007). WB ; Human . PubMed: 17287498
  • Costantini C  et al. An aging pathway controls the TrkA to p75NTR receptor switch and amyloid beta-peptide generation. EMBO J 25:1997-2006 (2006). PubMed: 16619032
  • Koppel J  et al. CALHM1 P86L polymorphism modulates CSF Aß levels in cognitively healthy individuals at risk for Alzheimer's disease. Mol Med 17:974-9 (0). PubMed: 21629967

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