For the best experience on the Abcam website please upgrade to a modern browser such as Google Chrome

We use cookies to make our site as useful as possible.

Our Cookie Policy explains how you can opt-out of the cookies we use.

If you continue without changing your cookie settings, we'll assume you’re happy with this.

Continue Continue

United States
Your country/region is currently set to:

If incorrect, please enter your country/region into the box below, to view site information related to your country/region.

Call (888) 77-ABCAM (22226) or contact us
Need help? Contact us

  • My account
  • Sign out
Sign in or Register with us

Welcome

Sign in or

Don't have an account?

Register with us
My basket
Quick order
Abcam homepage

  • Research Products
    By product type
    Primary antibodies
    Secondary antibodies
    ELISA and Matched Antibody Pair Kits
    Cell and tissue imaging tools
    Cellular and biochemical assays
    Proteins and Peptides
    By product type
    Proteomics tools
    Agonists, activators, antagonists and inhibitors
    Cell lines and Lysates
    Multiplex miRNA assays
    Multiplex Assays
    By research area
    Cancer
    Cardiovascular
    Cell Biology
    Epigenetics
    Metabolism
    Developmental Biology
    By research area
    Immunology
    Microbiology
    Neuroscience
    Signal Transduction
    Stem Cells
  • Diagnostic & Therapeutic Solutions
    Custom solutions & partnerships

    Custom antibody development and commercial partnerships to advance your diagnostic and therapeutic discovery.

    Create custom solutions with us

    Partner with us

  • Support
    Support hub

    Access advice and support for any research roadblock

    View support hub

    Protocols

    Your experiments laid out step by step

    View protocols

  • Events
    • Conference calendar
    • Cancer
    • Cardiovascular
    • Epigenetics & Nuclear signaling
    • Immunology
    • Neuroscience
    • Stem cells
    • Tradeshows
    • Scientific webinars
    Keep up to date with the latest events

    Full event breakdown with abstracts, speakers, registration and more

    View global event calendar

  • Pathways
    Cell signalling pathways

    View all pathways

    View all interactive pathways

Supporting our customers and employees during the COVID-19 pandemic. Read more

  1. Link

    bace2-antibody-ab8024.pdf

  1. Send me a copy of this email
    I agree to the terms and conditions.
Neuroscience Neurology process Neurodegenerative disease Alzheimer's disease Proteases
Share by email

Anti-BACE2 antibody (ab8024)

  • Datasheet
  • SDS
Submit a review Submit a question

Product price, shipping and contact information

Currently unavailable

Sorry, we can't display this right now.

Please contact us to place your order, or try again later.

 

Loading size & price…

 

Shipping and order information

Abpromise

Guaranteed product quality, expert customer support.

Find out more.

Western blot - Anti-BACE2 antibody (ab8024)
  • Western blot - Anti-BACE2 antibody (ab8024)
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-BACE2 antibody (ab8024)

Key features and details

  • Rabbit polyclonal to BACE2
  • Suitable for: IHC-P, WB
  • Reacts with: Rat, Human
  • Isotype: IgG

You may also be interested in

Secondary
Product image
Goat Anti-Rabbit IgG H&L (HRP) (ab205718)

View more associated products

Overview

  • Product name

    Anti-BACE2 antibody
    See all BACE2 primary antibodies
  • Description

    Rabbit polyclonal to BACE2
  • Host species

    Rabbit
  • Tested Applications & Species

    Application Species
    IHC-P
    Rat
    WB
    Human
    See all applications and species data
  • Immunogen

    Synthetic peptide, corresponding to amino acids 496-511 of Human BACE 2.

  • General notes

    Beta-site APP Cleaving Enzyme

    The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing the problem with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation.

    One factor contributing to the crisis is the use of antibodies that are not suitable. This can lead to misleading results and the use of incorrect data informing project assumptions and direction. To help address this challenge, we have introduced an application and species grid on our primary antibody datasheets to make it easy to simplify identification of the right antibody for your needs.

    Learn more here.

Properties

  • Form

    Liquid
  • Storage instructions

    Shipped at 4°C. Store at +4°C.
  • Storage buffer

    pH: 7.2
    Preservative: 0.02% Sodium azide
  • Concentration information loading...
  • Purity

    Affinity purified
  • Clonality

    Polyclonal
  • Isotype

    IgG
  • Research areas

    • Neuroscience
    • Neurology process
    • Neurodegenerative disease
    • Alzheimer's disease
    • Proteases
    • Cell Biology
    • Proteolysis / Ubiquitin
    • Proteolytic enzymes
    • Aspartic protease
    • BACEs

Associated products

  • Compatible Secondaries

    • Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (ab150077)
    • Goat Anti-Rabbit IgG H&L (HRP) (ab205718)
  • Isotype control

    • Rabbit IgG, polyclonal - Isotype Control (ChIP Grade) (ab171870)

Applications

The Abpromise guarantee

Our Abpromise guarantee covers the use of ab8024 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Guaranteed

Tested applications are guaranteed to work and covered by our Abpromise guarantee.

Predicted

Predicted to work for this combination of applications and species but not guaranteed.

Incompatible

Does not work for this combination of applications and species.

Application Species
IHC-P
Rat
WB
Human
Application Abreviews Notes
IHC-P
Use a concentration of 2 µg/ml.
WB
Use a concentration of 0.5 - 1 µg/ml.
Notes
IHC-P
Use a concentration of 2 µg/ml.
WB
Use a concentration of 0.5 - 1 µg/ml.

Target

  • Function

    Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves APP, between residues 690 and 691, leading to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase. It has also been shown that it can cleave APP between residues 671 and 672.
  • Tissue specificity

    Brain. Present in neurons within the hippocampus, frontal cortex and temporal cortex (at protein level). Expressed at low levels in most peripheral tissues and at higher levels in colon, kidney, pancreas, placenta, prostate, stomach and trachea. Expressed at low levels in the brain. Found in spinal cord, medulla oblongata, substantia nigra and locus coruleus. Expressed in the ductal epithelium of both normal and malignant prostate.
  • Sequence similarities

    Belongs to the peptidase A1 family.
  • Post-translational
    modifications

    Undergoes autoproteolytic cleavage.
    Glycosylated.
  • Cellular localization

    Membrane. Golgi apparatus. Endoplasmic reticulum. Endosome. Cell surface.
  • Target information above from: UniProt accession Q9Y5Z0 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt
  • Database links

    • Entrez Gene: 25825 Human
    • Entrez Gene: 288227 Rat
    • Omim: 605668 Human
    • SwissProt: Q9Y5Z0 Human
    • SwissProt: Q6IE75 Rat
    • Unigene: 529408 Human
    • Unigene: 38581 Rat
    • Alternative names

      • ALP 56 antibody
      • ALP56 antibody
      • Asp 1 antibody
      • ASP1 antibody
      • ASP21 antibody
      • Aspartic Like Protease 56kDa antibody
      • Aspartic-like protease 56 kDa antibody
      • Aspartyl protease 1 antibody
      • BACE 2 antibody
      • Bace2 antibody
      • BACE2_HUMAN antibody
      • Beta Secretase 2 antibody
      • Beta Site Amyloid Beta A4 Precursor Protein Cleaving Enzyme 2 antibody
      • Beta-secretase 2 antibody
      • Beta-site amyloid precursor protein cleaving enzyme 2 antibody
      • Beta-site APP cleaving enzyme 2 antibody
      • Down region aspartic protease antibody
      • Downs Syndrome Region Aspartic Protease antibody
      • DRAP antibody
      • Memapsin 1 antibody
      • Memapsin-1 antibody
      • Membrane associated aspartic protease 1 antibody
      • Membrane-associated aspartic protease 1 antibody
      • Theta-secretase antibody
      see all

    Images

    • Western blot - Anti-BACE2 antibody (ab8024)
      Western blot - Anti-BACE2 antibody (ab8024)
      Western Blot of human heart lysate labeling BACE2 with Anti-BACE2 antibody (ab8024) at 1µg/ml in (1) the absence and (2) the presence of blocking peptide..
    • Western blot - Anti-BACE2 antibody (ab8024)
      Western blot - Anti-BACE2 antibody (ab8024)
      All lanes : Anti-BACE2 antibody (ab8024) at 1 µg/ml

      Lane 1 : human heart tissue lysate with absence of blocking peptide
      Lane 2 : human heart tissue lysate with presence of blocking peptide
    • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-BACE2 antibody (ab8024)
      Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-BACE2 antibody (ab8024)
      Immunohistochemistry of BACE2 in rat heart tissue with BACE2 antibody at 2 µg/ml.

    Protocols

    • Western blot protocols
    • Immunohistochemistry protocols

    Click here to view the general protocols

    Datasheets and documents

    • SDS download

    • Datasheet download

      Download

    References (0)

    Publishing research using ab8024? Please let us know so that we can cite the reference in this datasheet.

    ab8024 has not yet been referenced specifically in any publications.

    Customer reviews and Q&As

    Show All Reviews Q&A
    Submit a review Submit a question

    There are currently no Customer reviews or Questions for ab8024.
    Please use the links above to contact us or submit feedback about this product.

    Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES"
    For licensing inquiries, please contact partnerships@abcam.com

    Get resources and offers direct to your inbox Sign up
    A-Z by research area
    • Cancer
    • Cardiovascular
    • Cell biology
    • Developmental biology
    • Epigenetics & Nuclear signaling
    • Immunology
    • Metabolism
    • Microbiology
    • Neuroscience
    • Signal transduction
    • Stem cells
    A-Z by product type
    • Primary antibodies
    • Secondary antibodies
    • Biochemicals
    • Isotype controls
    • Flow cytometry multi-color selector
    • Kits
    • Loading controls
    • Lysates
    • Peptides
    • Proteins
    • Slides
    • Tags and cell markers
    • Tools & Reagents
    Help & support
    • Support
    • Make an Inquiry
    • Protocols & troubleshooting
    • Placing an order
    • RabMAb products
    • Biochemical product FAQs
    • Training
    • Browse by Target
    Company
    • Corporate site
    • Investor relations
    • Company news
    • Careers
    • About us
    • Blog
    Events
    • Tradeshows
    • Conferences
    International websites
    • abcam.cn
    • abcam.co.jp

    Join with us

    • LinkedIn
    • facebook
    • Twitter
    • YouTube
    • Terms of sale
    • Website terms of use
    • Cookie policy
    • Privacy policy
    • Legal
    • Modern slavery statement
    © 1998-2021 Abcam plc. All rights reserved.