Product nameBacitracin, Peptide antibiotic
Potent antibiotic. Mixture of related cyclic polypeptides produced by organisms of the licheniformis group of Bacillus subtilis var Tracy, which disrupts gram positive and some gram negative bacteria by interfering with cell wall and peptidoglycan synthesis. Acts bactericidally by binding to isoprenyl pyrophosphate, the lipid carrier that transfers N-acetylmuramyl-N-acetylglucosamyl-amino acid cell wall building blocks across the cytoplasmic membrane. Inhibits enzymatic dephosphorylation of C55-isoprenyl pyrophosphate.
Storage instructionsStore at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
Solubility overviewSoluble in DMSO to 50 mM and in water to 50 mM
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
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This product has been referenced in:
- Toscano WA & Storm DR Bacitracin. Pharmacol Ther 16:199-210 (1982). Read more (PubMed: 6752975) »
- Roth RA Bacitracin: an inhibitor of the insulin degrading activity of glutathione-insulin transhydrogenase. Biochem Biophys Res Commun 98:431-8 (1981). Read more (PubMed: 7013763) »
- Stone KJ & Strominger JL Mechanism of action of bacitracin: complexation with metal ion and C 55 -isoprenyl pyrophosphate. Proc Natl Acad Sci U S A 68:3223-7 (1971). Read more (PubMed: 4332017) »