Key features and details
- Mouse monoclonal [11C1] to BAFF-R
- Suitable for: IHC-P, Flow Cyt, IHC-Fr
- Reacts with: Human
- Isotype: IgG1
Product nameAnti-BAFF-R antibody [11C1]
See all BAFF-R primary antibodies
DescriptionMouse monoclonal [11C1] to BAFF-R
Tested applicationsSuitable for: IHC-P, Flow Cyt, IHC-Frmore details
Species reactivityReacts with: Human
Tissue, cells or virus corresponding to Human BAFF-R. transfected mouse B cell lymphoma L1.2 cells
- IHC-P: human tonsil FACS: CD19+ B cells from tonsil.
Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
Concentration information loading...
PurityProtein G purified
Our Abpromise guarantee covers the use of ab16232 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
IHC-Fr: Use at an assay dependent dilution.
IHC-P: Use at an assay dependent dilution. Antigen retrieval with EDTA based solution (pH9.0) and heat.
Not tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
FunctionB-cell receptor specific for TNFSF13B/TALL1/BAFF/BLyS. Promotes the survival of mature B-cells and the B-cell response.
Tissue specificityHighly expressed in spleen and lymph node, and in resting B-cells. Detected at lower levels in activated B-cells, resting CD4+ T-cells, in thymus and peripheral blood leukocytes.
Involvement in diseaseDefects in TNFRSF13C are the cause of immunodeficiency common variable type 4 (CVID4) [MIM:613494]; also called antibody deficiency due to BAFFR defect. CVID4 is a primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of immunoglobulins; the numbers of circulating B cells is usually in the normal range, but can be low.
Sequence similaritiesContains 1 TNFR-Cys repeat.
- Information by UniProt
- B cell activating factor receptor antibody
- B-cell-activating factor receptor antibody
- BAFF R antibody
ab16232 has been referenced in 6 publications.
- Carrillo-Ballesteros FJ et al. B-cell activating factor receptor expression is associated with germinal center B-cell maintenance. Exp Ther Med 17:2053-2060 (2019). PubMed: 30783477
- Chong BF et al. Differential expression of BAFF and its receptors in discoid lupus erythematosus patients. J Dermatol Sci N/A:N/A (2013). Human . PubMed: 24315762
- Li YJ et al. Expression of BAFF and BAFF-R in follicular lymphoma: correlation with clinicopathologic characteristics and survival outcomes. PLoS One 7:e50936 (2012). IHC . PubMed: 23272079
- Di Carlo E et al. The lack of epithelial interleukin-7 and BAFF/BLyS gene expression in prostate cancer as a possible mechanism of tumor escape from immunosurveillance. Clin Cancer Res 15:2979-87 (2009). IHC-P ; Human . PubMed: 19366834
- Langat DL et al. Signaling pathways for B cell-activating factor (BAFF) and a proliferation-inducing ligand (APRIL) in human placenta. Am J Pathol 172:1303-11 (2008). IHC-Fr ; Human . PubMed: 18403603
- Ng LG et al. B cell-activating factor belonging to the TNF family (BAFF)-R is the principal BAFF receptor facilitating BAFF costimulation of circulating T and B cells. J Immunol 173:807-17 (2004). PubMed: 15240667