Overview

  • Product name

    Bafilomycin B1, macrolide antibiotic
  • Description

    Macrolide antibiotic. Potent, selective vacuolar-type H+-ATPase inhibitor.
  • Biological description

    Macrolide antibiotic. Potent and selective vacuolar-type H+-ATPase inhibitor. Orally active.
  • Purity

    > 97%
  • CAS Number

    88899-56-3
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    [(2R,4R,5S,6R)-2-Hydroxy-2-[(2S,3R,4S)-3-hydroxy-4-[(2R,3S,6Z,9S,10S,11R,12E,14E)-10-hydroxy-3,15-dimethoxy-7,9,11,13-tetramethyl-6-oxo-1-oxacyclohexadeca-4,6,12,14-tetraen-2-yl]pentan-2-yl]-5-methyl-6-propan-2-yloxan-4-yl] (E)-4-[(2-hydroxy-5-oxocyclopenten-1-yl)amino]-4-oxobut-2-enoate
  • Molecular weight

    815.99
  • Molecular formula

    C44H65NO13
  • PubChem identifier

    71312233
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in DMSO to 5 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Toxic, refer to SDS for further information.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CC1CC(=CC=CC(C(OC(=O)C(=CC(=CC(C1O)C)C)OC)C(C)C(C(C)C2(CC(C(C(O2)C(C)C)C)OC(=O)C=CC(=O)NC3=C(CCC3=O)O)O)O)OC)C
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Hettiarachchi KD  et al. Transplacental exposure to the vacuolar-ATPase inhibitor bafilomycin disrupts survival signaling in beta cells and delays neonatal remodeling of the endocrine pancreas. Exp Toxicol Pathol 60:295-306 (2008). Read more (PubMed: 18486461) »
  • Schuhmann T & Grond S Biosynthetic investigations of the V-type ATPase inhibitors bafilomycin A1, B1 and concanamycin A. J Antibiot (Tokyo) 57:655-61 (2004). Read more (PubMed: 15638326) »
  • Naganuma S  et al. Inhibition of the accumulation of lipid droplets in macrophage J774 by bafilomycin B1 and destruxin E. Biochim Biophys Acta 1126:41-8 (1992). Read more (PubMed: 1606174) »

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab143365.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
For licensing inquiries, please contact partnerships@abcam.com

Sign up