Bafilomycin C1, Vacuolar-type H+-ATPase inhibitor. (ab144203)

Overview

  • Product name

    Bafilomycin C1, Vacuolar-type H+-ATPase inhibitor.
  • Description

    Vacuolar-type H+-ATPase inhibitor. Na+,K+-ATPase inhibitor. Macrolide antibiotic agent.
  • Biological description

    Selective vacuolar-type H+-ATPase inhibitor. Na+,K+-ATPase inhibitor. Macrolide antibiotic agent. Shows bacteriostatic effects against Gram-positive bacteria. Shows antifungal effects.
  • Purity

    > 98%
  • CAS Number

    88979-61-7
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    (E)-4-[(2R,4R,5S,6R)-2-Hydroxy-2-[(2S,3R,4S)-3-hydroxy-4-[(3S,4Z,6E,9S,10S,11R,12E,14Z)-10-hydroxy-3,15-dimethoxy-7,9,11,13-tetramethyl-16-oxo-1-oxacyclohexadeca-4,6,12,14-tetraen-2-yl]pentan-2-yl]-5-methyl-6-propan-2-yloxan-4-yl]oxy-4-oxobut-2-enoic acid
  • Molecular weight

    720.89
  • Molecular formula

    C39H60O12
  • PubChem identifier

    6441158
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in ethanol and in DMSO
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Toxic, refer to SDS for further information.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    C[C@H]1C/C(=C/C=C\[C@@H](C(OC(=O)/C(=C/C(=C/[C@H]([C@H]1O)C)/C)/OC)[C@@H](C)[C@H]([C@H](C)[C@]2(C[C@H]([C@@H]([C@H](O2)C(C)C)C)OC(=O)/C=C/C(=O)O)O)O)OC)/C
  • Source

    Streptomyces sp.

  • Research areas

References

This product has been referenced in:

  • O'Shea MG  et al. Absolute configurations of macrolide antibiotics of the bafilomycin and leucanicidin groups. J Antibiot (Tokyo) 50:1073-7 (1997). Read more (PubMed: 9510919) »
  • Rautiala TJ  et al. Purification of vacuolar ATPase with bafilomycin C1 affinity chromatography. Biochem Biophys Res Commun 194:50-6 (1993). Read more (PubMed: 8333864) »
  • Bowman EJ  et al. Bafilomycins: a class of inhibitors of membrane ATPases from microorganisms, animal cells, and plant cells. Proc Natl Acad Sci U S A 85:7972-6 (1988). Read more (PubMed: 2973058) »

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