Key features and details
- Bioreductive AQ4 precursor. Topoisomerase II inhibitor.
- CAS Number: 252979-56-9
- Purity: > 97%
- Soluble in water to 25 mM
- Form / State: Solid
- Source: Synthetic
Product nameBanoxantrone dihydrochloride (AQ4N), Topoisomerase II inhibitor
DescriptionBioreductive AQ4 precursor. Topoisomerase II inhibitor.
Bioreductive AQ4 precursor. Topoisomerase II inhibitor. Converts under hypoxia to DNA-affinic mitoxantrone (ab141041) structural analog. Induces DNA intercalation. Shows antitumor effects in vivo.
Chemical name1,4-Bis[[2-(dimethyloxidoamino)ethyl]amino]-5,8-dihydroxy-9,10-anthracenedione dihydrochloride
Storage instructionsStore at -20°C. It is important to note that this product is reported to be light sensitive. Store In the Dark. Store under desiccating conditions.
Solubility overviewSoluble in water to 25 mM
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
ab144573 has been referenced in 1 publication.
- Zhang R et al. Glucose & oxygen exhausting liposomes for combined cancer starvation and hypoxia-activated therapy. Biomaterials 162:123-131 (2018). PubMed: 29438880