Banoxantrone dihydrochloride (AQ4N), Topoisomerase II inhibitor (ab144573)

Overview

  • Product name
    Banoxantrone dihydrochloride (AQ4N), Topoisomerase II inhibitor
  • Description
    Bioreductive AQ4 precursor. Topoisomerase II inhibitor.
  • Biological description
    Bioreductive AQ4 precursor. Topoisomerase II inhibitor. Converts under hypoxia to DNA-affinic mitoxantrone (ab141041) structural analog. Induces DNA intercalation. Shows antitumor effects in vivo.
  • Purity
    > 98%

Properties

References

This product has been referenced in:
  • Ming L  et al. Androgen deprivation results in time-dependent hypoxia in LNCaP prostate tumours: informed scheduling of the bioreductive drug AQ4N improves treatment response. Int J Cancer 132:1323-32 (2013). Read more (PubMed: 22915157) »
  • Manley E & Waxman DJ Impact of tumor blood flow modulation on tumor sensitivity to the bioreductive drug banoxantrone. J Pharmacol Exp Ther 344:368-77 (2013). Read more (PubMed: 23192656) »
  • Hejmadi MV  et al. DNA damage following combination of radiation with the bioreductive drug AQ4N: possible selective toxicity to oxic and hypoxic tumour cells. Br J Cancer 73:499-505 (1996). Read more (PubMed: 8595165) »
See 1 Publication for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"

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