Key features and details
- Mouse monoclonal [BP-1] to BAP1
- Suitable for: WB
- Reacts with: Rat, Human
- Isotype: IgG1
Product nameAnti-BAP1 antibody [BP-1]
See all BAP1 primary antibodies
DescriptionMouse monoclonal [BP-1] to BAP1
Tested applicationsSuitable for: WBmore details
Species reactivityReacts with: Rat, Human
Recombinant full length Human BAP1.
- Rat testicular and ovarian tissue lysates.
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In preparation for this, we have started to update the applications & species that this product is Abpromise guaranteed for.
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Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term.
Storage bufferpH: 7.2
Preservative: 0.001% Sodium azide
Constituents: 1.2% Sodium acetate, 0.2% BSA
Concentration information loading...
PurityProtein G purified
Purification notesPurified by the goat anti-mouse IgG affinity chromatography.
Our Abpromise guarantee covers the use of ab130202 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|WB||Use a concentration of 0.5 µg/ml. Predicted molecular weight: 80 kDa.|
FunctionDeubiquitinating enzyme that plays a key role in chromatin by mediating deubiquitination of histone H2A and HCFC1. Catalytic component of the PR-DUB complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-119' (H2AK119ub1). Does not deubiquitinate monoubiquitinated histone H2B. Acts as a regulator of cell growth by mediating deubiquitination of HCFC1 N-terminal and C-terminal chains, with some specificity toward 'Lys-48'-linked polyubiquitin chains compared to 'Lys-63'-linked polyubiquitin chains. Deubiquitination of HCFC1 does not lead to increase stability of HCFC1. Interferes with the BRCA1 and BARD1 heterodimer activity by inhibiting their ability to mediate ubiquitination and autoubiquitination. It however does not mediate deubiquitination of BRCA1 and BARD1. Acts as a tumor suppressor.
Tissue specificityHighly expressed in testis, placenta and ovary. Expressed in breast.
Sequence similaritiesBelongs to the peptidase C12 family. BAP1 subfamily.
modificationsPhosphorylated upon DNA damage, probably by ATM or ATR.
Cellular localizationCytoplasm. Nucleus. Mainly nuclear. Binds to chromatin.
- Information by UniProt
- BAP 1 antibody
- Bap1 antibody
- BAP1_HUMAN antibody
ab130202 has not yet been referenced specifically in any publications.