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    bax-channel-blocker-mitochondrial-cytochrome-c-release-inhibitor-ab145899.pdf

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Bax Channel Blocker, mitochondrial cytochrome c release inhibitor (ab145899)

  • Datasheet
  • SDS
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  • Datasheet
  • References

Overview

  • Product name

    Bax Channel Blocker, mitochondrial cytochrome c release inhibitor
  • Description

    Bax-mediated mitochondrial cytochrome c release inhibitor
  • Alternative names

    • 1-(3,6-dibromo-9H-carbazol-9-yl)-3-(piperazin-1-yl)propan-2-ol
    • bis TFA
    • iMAC1
  • Biological description

    Cell-permeable dibromocarbazolo-piperazinyl derivative that displays anti-apoptotic properties. Blocks Bid-induced cytochrome c release from HeLa cell mitochondria by inhibiting Bax channel forming activitiy.

  • Purity

    > 95%
  • CAS Number

    335165-69-9
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    1-(3,6-Dibromo-9H-carbazol-9-yl)-3-(piperazin-1-yl)propan-2-ol trifluoroacetate
  • Molecular weight

    695.30
  • Molecular formula

    C19H21Br2N3O.2CF3CO2H
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in DMSO
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • Source

    Synthetic

Datasheets and documents

    • Datasheet
    • SDS
  • References

    This product has been referenced in:

    • Peixoto PM  et al. MAC inhibitors suppress mitochondrial apoptosis. Biochem J 423:381-7 (2009). Read more (PubMed: 19691447) »
    • Bombrun A  et al. 3,6-dibromocarbazole piperazine derivatives of 2-propanol as first inhibitors of cytochrome c release via Bax channel modulation. J Med Chem 46:4365-8 (2003). Read more (PubMed: 14521400) »

    Publishing research using ab145899? Please let us know so that we can cite the reference in this datasheet.

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    Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
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