BAY 11-7082, IkappaBalpha kinase inhibitor (ab141228)
Key features and details
- IκBα kinase inhibitor. NF-κB inhibitor. Apoptosis inducer. Inhibits the release of proinflammatory cytokines. Inflammasome inhibitor. Platelet aggregation inhibitor.
- CAS Number: 19542-67-7
- Purity: > 99%
- Soluble in ethanol to 50 mM and in DMSO to 100 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
BAY 11-7082, IkappaBalpha kinase inhibitor -
Description
IκBα kinase inhibitor. NF-κB inhibitor. Apoptosis inducer. Inhibits the release of proinflammatory cytokines. Inflammasome inhibitor. Platelet aggregation inhibitor. -
Purity
> 99% -
CAS Number
19542-67-7 -
Chemical structure
Properties
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Chemical name
(E)-3-(4-methylphenyl)sulfonylprop-2-enenitrile -
Molecular weight
207.25 -
Molecular formula
C10H9NO2S -
PubChem identifier
5353431 -
Storage instructions
Store at -20°C. Store In the Dark. Store under desiccating conditions. This product is air and light sensitive and impurities can occur as a result of air oxidation or due to metabolism by microbes. -
Solubility overview
Soluble in ethanol to 50 mM and in DMSO to 100 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Refer to SDS for further information.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
CC1=CC=C(C=C1)S(=O)(=O)/C=C/C#N -
Source
Synthetic
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Research areas
Protocols
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
Datasheets and documents
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SDS download
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Datasheet download
References (12)
ab141228 has been referenced in 12 publications.
- Liu X et al. Glial cell line-derived neurotrophic factor contributes to alcoholic-induced liver injury by regulating the NF-κB pathway. Alcohol Clin Exp Res 46:724-735 (2022). PubMed: 35338490
- Kemp SB et al. Apolipoprotein E Promotes Immune Suppression in Pancreatic Cancer through NF-?B-Mediated Production of CXCL1. Cancer Res 81:4305-4318 (2021). PubMed: 34049975
- Gao Y et al. Fusobacterium nucleatum enhances the efficacy of PD-L1 blockade in colorectal cancer. Signal Transduct Target Ther 6:398 (2021). PubMed: 34795206
- Salomies L et al. The developmental origins of heterodonty and acrodonty as revealed by reptile dentitions. Sci Adv 7:eabj7912 (2021). PubMed: 34919438
- Sheng J et al. Treatment of Retinoblastoma 1-Intact Hepatocellular Carcinoma With Cyclin-Dependent Kinase 4/6 Inhibitor Combination Therapy. Hepatology 74:1971-1993 (2021). PubMed: 33931882