BAY 11-7085, Irreversible inhibitor of TNF-alpha-induced IxBalpha phosphorylation (ab141574)

Overview

  • Product name

    BAY 11-7085, Irreversible inhibitor of TNF-alpha-induced IxBalpha phosphorylation
  • Description

    Irreversible inhibitor of TNF-α-induced IxBα phosphorylation
  • Biological description

    Irreversibly inhibits TNF-α-induced IxBα phosphorylation. Reduces NF-κB and adhesion molecules (IC50 = 5-10 μM). Anti-inflammatory, anti cancer and neuroprotective agent in vivo.
  • Purity

    > 99%
  • CAS Number

    196309-76-9
  • Chemical structure

    Chemical Structure

Properties

References

This product has been referenced in:

  • Lee J  et al. BAY 11-7082 is a broad-spectrum inhibitor with anti-inflammatory activity against multiple targets. Mediators Inflamm 2012:416036 (2012). Read more (PubMed: 22745523) »
  • Kim YS  et al. BAY 11-7082, a nuclear factor-?B inhibitor, reduces inflammation and apoptosis in a rat cardiac ischemia-reperfusion injury model. Int Heart J 51:348-53 (2010). Read more (PubMed: 20966608) »
  • Pierce JW  et al. Novel inhibitors of cytokine-induced IkappaBalpha phosphorylation and endothelial cell adhesion molecule expression show anti-inflammatory effects in vivo. J Biol Chem 272:21096-103 (1997). Read more (PubMed: 9261113) »

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