Key features and details
- Irreversible inhibitor of TNF-α-induced IxBα phosphorylation
- CAS Number: 196309-76-9
- Purity: > 99%
- Soluble in DMSO to 100 mM and in ethanol to 100 mM
- Form / State: Solid
- Source: Synthetic
Product nameBAY 11-7085, Irreversible inhibitor of TNF alpha-induced IxBalpha phosphorylation
DescriptionIrreversible inhibitor of TNF-α-induced IxBα phosphorylation
Biological descriptionIrreversibly inhibits TNF-α-induced IxBα phosphorylation. Reduces NF-κB and adhesion molecules (IC50 = 5-10 μM). Anti-inflammatory, anti cancer and neuroprotective agent in vivo.
Storage instructionsStore at Room Temperature. The product can be stored for up to 12 months.
Solubility overviewSoluble in DMSO to 100 mM and in ethanol to 100 mM
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
ab141574 has been referenced in 2 publications.
- Suenaga N et al. Loss of Tumor Suppressor CYLD Expression Triggers Cisplatin Resistance in Oral Squamous Cell Carcinoma. Int J Mol Sci 20:N/A (2019). PubMed: 31635163
- Fang H et al. NF-?B signaling pathway inhibition suppresses hippocampal neuronal apoptosis and cognitive impairment via RCAN1 in neonatal rats with hypoxic-ischemic brain damage. Cell Cycle 18:1001-1018 (2019). PubMed: 30990350