Overview

  • Product name

    Bay 61-3606 hydrochloride, Syk kinase inhibitor
  • Description

    Potent, selective, cell-permeable Syk kinase inhibitor
  • Biological description

    Potent, selective, cell permeable Syk kinase inhibitor (Ki value = 7.5 nM). Inhibits degranulation in vitro (IC50 = 10 nM). Anti-inflammatory. Orally active. Active in vitro and in vivo.
  • Purity

    > 98%
  • CAS Number

    732938-37-8
  • Chemical structure

    Chemical Structure

Properties

References

This product has been referenced in:

  • Lau KS  et al. BAY61-3606 affects the viability of colon cancer cells in a genotype-directed manner. PLoS One 7:e41343 (2012). Read more (PubMed: 22815993) »
  • Mitra R  et al. BAY 61-3606, CDKi, and sodium butyrate treatments alter gene expression in human vestibular schwannomas and cause cell death in vitro. Ecancermedicalscience 6:285 (2012). Read more (PubMed: 23304241) »
  • Yamamoto N  et al. The orally available spleen tyrosine kinase inhibitor 2-[7-(3,4-dimethoxyphenyl)-imidazo[1,2-c]pyrimidin-5-ylamino]nicotinamide dihydrochloride (BAY 61-3606) blocks antigen-induced airway inflammation in rodents. J Pharmacol Exp Ther 306:1174-81 (2003). Read more (PubMed: 12766258) »
See 1 Publication for this product

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