Overview

  • Product name

  • Description

    Goat polyclonal to BBF2H7
  • Host species

    Goat
  • Tested applications

    Suitable for: WBmore details
  • Species reactivity

    Reacts with: Mouse, Rat
    Predicted to work with: Cow, Dog, Human
  • Immunogen

    Synthetic peptide corresponding to Human BBF2H7 aa 413-426 (internal sequence) (Cysteine residue). NP_919047.2
    Sequence:

    HSLQEPYTASVVRS


    Database link: Q70SY1

  • Positive control

    • Rat testis lysate
  • General notes

     This product was previously labelled as CREB3L2

     

Properties

Applications

Our Abpromise guarantee covers the use of ab181490 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 - 3 µg/ml. Detects a band of approximately 55 kDa (predicted molecular weight: 57 kDa).

Target

  • Function

    Transcriptional activator which is processed and activated during endoplasmic reticulum stress late phase. Binds to the cAMP response element (CRE) and activates transcription through CRE. Regulates the transcription of unfolded protein response target genes, preventing accumulation of unfolded proteins in damaged neurons. Also regulates the expression of SEC23A, accelerating protein trafficking from the ER to the Golgi thereby playing a key role in chondrocyte differentiation and formation of epiphyseal cartilage.
  • Tissue specificity

    Widely expressed with highest levels in placenta, lung, spleen and intestine, and lowest levels in heart, brain, skeletal muscle, thymus, colon and leukocytes. In fetal tissues, the weakest expression is detected in brain and heart.
  • Involvement in disease

    A chromosomal aberration involving CREB3L2 is found in low grade fibromyxoid sarcoma (LGFMS). Translocation t(7;16)(q33;p11) with FUS.
  • Sequence similarities

    Belongs to the bZIP family. ATF subfamily.
    Contains 1 bZIP (basic-leucine zipper) domain.
  • Post-translational
    modifications

    Controlled by regulated intramembrane proteolysis (RIP). Following ER stress a fragment containing the cytoplasmic transcription factor domain is released by proteolysis. The cleavage seems to be performed sequentially by site-1 and site-2 proteases (PS1 and PS2).
  • Cellular localization

    Endoplasmic reticulum membrane and Nucleus. Under ER stress the cleaved N-terminal cytoplasmic domain translocates into the nucleus.
  • Information by UniProt
  • Database links

  • Alternative names

    • B ZIB transcription factor antibody
    • Basic transcription factor 2 antibody
    • BBF2 human homolog on chromosome 7 antibody
    • BBF2H7 antibody
    • BZIB transcription factor antibody
    • cAMP responsive element binding protein 3 like 2 antibody
    • cAMP-responsive element-binding protein 3-like protein 2 antibody
    • CR3L2_HUMAN antibody
    • Creb3l2 antibody
    • Cyclic AMP-responsive element-binding protein 3-like protein 2 antibody
    • FUS/BBF2H7 protein antibody
    • MGC131709 antibody
    • MGC71006 antibody
    • Processed cyclic AMP-responsive element-binding protein 3-like protein 2 antibody
    • TCAG_1951439 antibody
    see all

Images

  • Anti-BBF2H7 antibody (ab181490) at 3 µg/ml + Rat testis lysate in RIPA buffer at 35 µg

    Developed using the ECL technique.

    Predicted band size: 57 kDa



    Primary incubation was 1 hour.

References

This product has been referenced in:

  • Krawczyk KK  et al. Assessing the contribution of thrombospondin-4 induction and ATF6a activation to endoplasmic reticulum expansion and phenotypic modulation in bladder outlet obstruction. Sci Rep 6:32449 (2016). WB ; Mouse . Read more (PubMed: 27581066) »
See 1 Publication for this product

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