• Product name

    Anti-BBS8 antibody
  • Description

    Goat polyclonal to BBS8
  • Host species

  • Specificity

    ab101731 is expected to recognize all reported isoforms (NP_653197.2; NP_938051.1; NP_938052.1).
  • Tested applications

    Suitable for: WBmore details
  • Species reactivity

    Reacts with: Human
    Predicted to work with: Mouse, Rat, Chicken, Cow, Dog, Pig
  • Immunogen

    Synthetic peptide corresponding to Human BBS8 aa 316-327 (internal sequence).


    Database link: NP_653197.2

  • Positive control

    • Human Testis lysate
  • General notes

     This product was previously labelled as TTC8



  • Form

  • Storage instructions

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.
  • Storage buffer

    Preservative: 0.02% Sodium Azide
    Constituents: 0.5% BSA, Tris buffered saline, pH 7.3
  • Concentration information loading...
  • Purity

    Immunogen affinity purified
  • Purification notes

    ab101731 was purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
  • Clonality

  • Isotype

  • Research areas


Our Abpromise guarantee covers the use of ab101731 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 0.2 - 0.6 µg/ml. Detects a band of approximately 60 kDa (predicted molecular weight: 62 kDa).


  • Function

    The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the guanosyl exchange factor (GEF) for Rab8 and then the Rab8-GTP localizes to the cilium and promotes docking and fusion of carrier vesicles to the base of the ciliary membrane.
  • Tissue specificity

    Widely expressed.
  • Involvement in disease

    Defects in TTC8 are the cause of retinitis pigmentosa type 51 (RP51) [MIM:613464]. It is a retinal dystrophy belonging to the group of pigmentary retinopathies. Retinitis pigmentosa is characterized by retinal pigment deposits visible on fundus examination and primary loss of rod photoreceptor cells followed by secondary loss of cone photoreceptors. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well.
    Defects in TTC8 are the cause of Bardet-Biedl syndrome type 8 (BBS8) [MIM:209900]. Bardet-Biedl syndrome (BBS) is a genetically heterogeneous, autosomal recessive disorder characterized by usually severe pigmentary retinopathy, early onset obesity, polydactyly, hypogenitalism, renal malformation and mental retardation. Secondary features include diabetes mellitus, hypertension and congenital heart disease. A relatively high incidence of BBS is found in the mixed Arab populations of Kuwait and in Bedouin tribes throughout the Middle East, most likely due to the high rate of consaguinity in these populations and a founder effect.
  • Sequence similarities

    Contains 8 TPR repeats.
  • Cellular localization

    Cytoplasm > cytoskeleton > centrosome. Cell projection > cilium membrane. Cytoplasm. Localizes to nonmembranous centriolar satellites in the cytoplasm.
  • Information by UniProt
  • Database links

  • Alternative names

    • Bardet Biedl syndrome 8 protein antibody
    • Bardet Biedl syndrome type 8 antibody
    • Bardet-Biedl syndrome 8 protein antibody
    • BBS8 antibody
    • RP51 antibody
    • Tetratricopeptide repeat domain 8 antibody
    • Tetratricopeptide repeat protein 8 antibody
    • TPR repeat protein 8 antibody
    • TTC 8 antibody
    • Ttc8 antibody
    • TTC8_HUMAN antibody
    see all


  • Anti-BBS8 antibody (ab101731) at 0.2 µg/ml + Human testis lysate in RIPA buffer at 35 µg

    Developed using the ECL technique.

    Predicted band size: 62 kDa

    Primary incubation was 1 hour.


ab101731 has not yet been referenced specifically in any publications.

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