Overview

  • Product name
  • Description
    Goat polyclonal to BCAR3
  • Host species
    Goat
  • Tested applications
    Suitable for: WB, ELISAmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Cow
  • Immunogen

    Synthetic peptide:

    RKLEPPPVKQAEL

    , corresponding to C terminal amino acids 813 - 825 of Human BCAR3.

Properties

  • Form
    Liquid
  • Storage instructions
    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • Storage buffer
    Preservative: 0.02% Sodium Azide
    Constituents: 0.5% BSA, Tris buffered saline. pH 7.3
  • Concentration information loading...
  • Purity
    Immunogen affinity purified
  • Clonality
    Polyclonal
  • Isotype
    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab21705 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 0.5 µg/ml.
ELISA Use at an assay dependent dilution.

Target

  • Function
    May act as an adapter protein and couple activated growth factor receptors to a signaling pathway that regulates the proliferation in breast cancer cells. When overexpressed, it confers anti-estrogen resistance in breast cancer cell lines. May also be regulated by cellular adhesion to extracellular matrix proteins.
  • Tissue specificity
    Ubiquitously expressed. Found in several cancer cell lines, but not in nonmalignant breast tissue.
  • Sequence similarities
    Contains 1 Ras-GEF domain.
    Contains 1 SH2 domain.
  • Information by UniProt
  • Database links
  • Alternative names
    • BCAR 3 antibody
    • BCAR3 antibody
    • BCAR3_HUMAN antibody
    • Breast cancer anti estrogen resistance 3 antibody
    • Breast cancer anti estrogen resistance protein 3 antibody
    • Breast cancer anti-estrogen resistance protein 3 antibody
    • Breast cancer antiestrogen resistance 3 antibody
    • dJ1033H22.2 antibody
    • dJ1033H22.2 breast cancer anti estrogen resistance 3 antibody
    • dJ1033H22.2 breast cancer antiestrogen resistance 3 antibody
    • KIAA0554 antibody
    • Novel SH2 containing protein 2 antibody
    • Novel SH2-containing protein 2 antibody
    • NSP 2 antibody
    • NSP2 antibody
    • SH2 containing protein Nsp2 antibody
    • SH2 domain containing protein 3B antibody
    • SH2 domain-containing protein 3B antibody
    • SH2D3B antibody
    see all

Images

  • Anti-BCAR3 antibody (ab21705) at 0.5 µg/ml + Cell lysates prepared from mouse kidney epithelial cells at 15 µg

References

ab21705 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

Answer

Thank you for your enquiry. We do not routinely offer free or trial sized samples for testing purposes. Goat polyclonal to BCAR3 (ab21705) is a fast track antibody and therefore as you mention any new details of application and species reactivity is highly valuable to us. We operate an incentive scheme that benefits our customers who leave feedback on the behaviour of the antibody. This is our Abpoints scheme and benefits our customers by providing them with points for an Abreview that can be redeemed against future purchases, Amazon vouchers, discounts at conferences etc. Due to the fact that this antibody has not been characterized using any application and is a fast track antibody we provide our reviews of this antibody with a significant number of points (1,000 Abpoints to the 1st researcher who submits conclusive data (positive or negative)). I hope this information helps, please do not hesitate to contact me should you require further assistance.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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