Anti-BFL-1/GRS antibody (ab45414)
Key features and details
- Rabbit polyclonal to BFL-1/GRS
- Suitable for: WB
- Reacts with: Human
- Isotype: IgG
Get better batch-to-batch reproducibility with a recombinant antibody
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- Success from the first experiment – confirmed specificity through extensive validation
- Ethical standards compliant – production is animal-free
Overview
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Product name
Anti-BFL-1/GRS antibody
See all BFL-1/GRS primary antibodies -
Description
Rabbit polyclonal to BFL-1/GRS -
Host species
Rabbit -
Specificity
At least two isoforms of Bcl2A1/GRS are known to exist; this antibody will detect both isoforms.
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Tested applications
Suitable for: WBmore details -
Species reactivity
Reacts with: Human -
Immunogen
Synthetic peptide corresponding to Human BFL-1/GRS (N terminal). A 14 amino acid peptide from near the amino terminus of human BFL-1/GRS
Database link: Q16548 -
Positive control
- WB: Human kidney tissue lysate.
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General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at +4°C. -
Storage buffer
pH: 7.2
Preservative: 0.02% Sodium azide
Constituent: PBS -
Concentration information loading...
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Purity
Immunogen affinity purified -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
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Positive Controls
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Recombinant Protein
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab45414 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
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WB |
Use a concentration of 1 - 2 µg/ml. Detects a band of approximately 39 kDa (predicted molecular weight: 20 kDa).
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Notes |
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WB
Use a concentration of 1 - 2 µg/ml. Detects a band of approximately 39 kDa (predicted molecular weight: 20 kDa). |
Target
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Function
Retards apoptosis induced by IL-3 deprivation. May function in the response of hemopoietic cells to external signals and in maintaining endothelial survival during infection. -
Tissue specificity
Seems to be restricted to the hematopoietic compartment. Expressed in peripheral blood, spleen, and bone marrow, at moderate levels in lung, small intestine and testis, at a minimal levels in other tissues. Also found in vascular smooth muscle cells and hematopoietic malignancies. -
Sequence similarities
Belongs to the Bcl-2 family. -
Cellular localization
Cytoplasm. - Information by UniProt
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Database links
- Entrez Gene: 597 Human
- Omim: 601056 Human
- SwissProt: Q16548 Human
- Unigene: 227817 Human
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Alternative names
- ACC 1 antibody
- ACC 2 antibody
- B2LA1_HUMAN antibody
see all
Images
Datasheets and documents
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SDS download
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Datasheet download
References (2)
ab45414 has been referenced in 2 publications.
- Liu F et al. UBQLN4 is an ATM substrate that stabilizes the anti-apoptotic proteins BCL2A1 and BCL2L10 in mesothelioma. Mol Oncol 15:3738-3752 (2021). PubMed: 34245648
- Gröschel M et al. Acute Noise Exposure Is Associated With Intrinsic Apoptosis in Murine Central Auditory Pathway. Front Neurosci 12:312 (2018). PubMed: 29867323