Overview

  • Product name

    Anti-BCMA antibody [1D12G9]
    See all BCMA primary antibodies
  • Description

    Mouse monoclonal [1D12G9] to BCMA
  • Host species

    Mouse
  • Tested applications

    Suitable for: WB, Flow Cytmore details
  • Species reactivity

    Reacts with: Human
  • Immunogen

    Recombinant fragment corresponding to Human BCMA aa 3-17. Expressed in E.coli.
    Sequence:

    QMAGQCSQNEYFDSLc


    Database link: Q02223

  • Positive control

    • WB: Human BCMA (aa 1-184)-hIgGFc-transfected HEK-293 cell lysate. Flow: K562 cells.

Properties

Applications

Our Abpromise guarantee covers the use of ab233745 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/2000. Predicted molecular weight: 20 kDa.
Flow Cyt 1/200 - 1/400.

Target

  • Function

    Receptor for TNFSF13B/BLyS/BAFF and TNFSF13/APRIL. Promotes B-cell survival and plays a role in the regulation of humoral immunity. Activates NF-kappa-B and JNK.
  • Tissue specificity

    Expressed in mature B-cells, but not in T-cells or monocytes.
  • Involvement in disease

    Note=A chromosomal aberration involving TNFRSF17 is found in a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(4;16)(q26;p13) with IL2.
  • Sequence similarities

    Contains 1 TNFR-Cys repeat.
  • Cellular localization

    Cell membrane. Endomembrane system. Perinuclear Golgi-like structures.
  • Information by UniProt
  • Database links

  • Alternative names

    • B cell maturation antigen antibody
    • B cell maturation factor antibody
    • B cell maturation protein antibody
    • B-cell maturation protein antibody
    • BCM antibody
    • BCMA antibody
    • CD269 antibody
    • CD269 antigen antibody
    • TNFRSF17 antibody
    • TNR17_HUMAN antibody
    • Tumor necrosis factor receptor superfamily member 17 antibody
    see all

Images

  • All lanes : Anti-BCMA antibody [1D12G9] (ab233745) at 1/500 dilution

    Lane 1 : HEK-293 (human epithelial cell line from embryonic kidney) cell lysate.
    Lane 2 : BCMA (AA: 1-184)-hIgGFc transfected HEK-293 cell lysate.

    Predicted band size: 20 kDa

  • Flow cytometric analysis of K562 (human chronic myelogenous leukemia cell line from bone marrow) cells labelling BCMA using ab233745 at 1/200 dilution (green) compared with a negative control (red).

References

ab233745 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab233745.
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