Key features and details
- Mouse monoclonal [BCMA/2366] to BCMA
- Suitable for: Protein Array, IHC-P, SDS-PAGE
- Reacts with: Human
- Isotype: IgG2b
Product nameAnti-BCMA antibody [BCMA/2366]
See all BCMA primary antibodies
DescriptionMouse monoclonal [BCMA/2366] to BCMA
Tested applicationsSuitable for: Protein Array, IHC-P, SDS-PAGEmore details
Species reactivityReacts with: Human
Recombinant fragment within Human BCMA aa 78-184. The exact sequence is proprietary.
Database link: Q02223
- IHC-P: Human gastric carcinoma tissue.
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Abcam is leading the way with our range of recombinant antibodies, knockout-validated antibodies and knockout cell lines, all of which support improved reproducibility.
We are also planning to innovate the way in which we present recommended applications and species on our product datasheets, so that only applications & species that have been tested in our own labs, our suppliers or by selected trusted collaborators are covered by our Abpromise™ guarantee.
In preparation for this, we have started to update the applications & species that this product is Abpromise guaranteed for.
We are also updating the applications & species that this product has been “predicted to work with,” however this information is not covered by our Abpromise guarantee.
Applications & species from publications and Abreviews that have not been tested in our own labs or in those of our suppliers are not covered by the Abpromise guarantee.
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Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
Storage bufferPreservative: 0.05% Sodium azide
Constituents: PBS, 0.05% BSA
Concentration information loading...
Purification notesPurified from bioreactor concentrate by Protein A/G.
Light chain typekappa
Our Abpromise guarantee covers the use of ab234407 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|Protein Array||Use at an assay dependent concentration.|
|IHC-P||Use a concentration of 1 - 2 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.
Staining of formalin-fixed tissues requires boiling tissue sections in 10 mM citrate buffer, pH 6.0, for 10-20 minutes followed by cooling at RT for 20 minutes. Incubate with primary antibody for 30 minutes at room temperature.
|SDS-PAGE||Use at an assay dependent concentration.|
FunctionReceptor for TNFSF13B/BLyS/BAFF and TNFSF13/APRIL. Promotes B-cell survival and plays a role in the regulation of humoral immunity. Activates NF-kappa-B and JNK.
Tissue specificityExpressed in mature B-cells, but not in T-cells or monocytes.
Involvement in diseaseNote=A chromosomal aberration involving TNFRSF17 is found in a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(4;16)(q26;p13) with IL2.
Sequence similaritiesContains 1 TNFR-Cys repeat.
Cellular localizationCell membrane. Endomembrane system. Perinuclear Golgi-like structures.
- Information by UniProt
- B cell maturation antigen antibody
- B cell maturation factor antibody
- B cell maturation protein antibody
ab234407 was tested in protein array against over 19000 different full-length human proteins.
Z- and S- Score: The Z-score represents the strength of a signal that a monoclonal antibody (MAb) (in combination with a fluorescently-tagged anti-IgG secondary antibody) produces when binding to a particular protein on the HuProtTM array. Z-scores are described in units of standard deviations (SD's) above the mean value of all signals generated on that array. If targets on HuProtTM are arranged in descending order of the Z-score, the S-score is the difference (also in units of SD's) between the Z-score. S-score therefore represents the relative target specificity of a MAb to its intended target.
A MAb is specific to its intended target if the MAb has an S-score of at least 2.5. For example, if a MAb binds to protein X with a Z-score of 43 and to protein Y with a Z-score of 14, then the S-score for the binding of that MAb to protein X is equal to 29.
Formalin-fixed, paraffin-embedded human gastric carcinoma tissue stained for BCMA using ab234407 at 2 μg/ml in immunohistochemical analysis.
SDS-PAGE - Anti-BCMA antibody [BCMA/2366] (ab234407) at 2 µg.
Lane 1: Non-reduced.
Lane 2: Reduced.
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
ab234407 has not yet been referenced specifically in any publications.