Overview

  • Product name

    Anti-BCMA antibody [BCMA/2366] - BSA and Azide free
    See all BCMA primary antibodies
  • Description

    Mouse monoclonal [BCMA/2366] to BCMA - BSA and Azide free
  • Host species

    Mouse
  • Tested applications

    Suitable for: Protein Array, IHC-Pmore details
  • Species reactivity

    Reacts with: Human
  • Immunogen

    Recombinant fragment within Human BCMA aa 78-184. The exact sequence is proprietary.
    Database link: Q02223

  • Positive control

    • IHC-P: Human gastric carcinoma tissue.

Properties

Applications

Our Abpromise guarantee covers the use of ab236326 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
Protein Array Use at an assay dependent concentration.
IHC-P Use a concentration of 1 - 2 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

Staining of formalin-fixed tissues requires boiling tissue sections in 10 mM citrate buffer, pH 6.0, for 10-20 minutes followed by cooling at RT for 20 minutes. Incubate with primary antibody for 30 minutes at room temperature.

Target

  • Function

    Receptor for TNFSF13B/BLyS/BAFF and TNFSF13/APRIL. Promotes B-cell survival and plays a role in the regulation of humoral immunity. Activates NF-kappa-B and JNK.
  • Tissue specificity

    Expressed in mature B-cells, but not in T-cells or monocytes.
  • Involvement in disease

    Note=A chromosomal aberration involving TNFRSF17 is found in a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(4;16)(q26;p13) with IL2.
  • Sequence similarities

    Contains 1 TNFR-Cys repeat.
  • Cellular localization

    Cell membrane. Endomembrane system. Perinuclear Golgi-like structures.
  • Information by UniProt
  • Database links

  • Alternative names

    • B cell maturation antigen antibody
    • B cell maturation factor antibody
    • B cell maturation protein antibody
    • B-cell maturation protein antibody
    • BCM antibody
    • BCMA antibody
    • CD269 antibody
    • CD269 antigen antibody
    • TNFRSF17 antibody
    • TNR17_HUMAN antibody
    • Tumor necrosis factor receptor superfamily member 17 antibody
    see all

Images

  • This data was produced with ab234407, the same antibody in a different formulation with BSA and Azide.
    ab234407 was tested in protein array against over 19000 different full-length human proteins.
    Z- and S- Score: The Z-score represents the strength of a signal that a monoclonal antibody (MAb) (in combination with a fluorescently-tagged anti-IgG secondary antibody) produces when binding to a particular protein on the HuProtTM array. Z-scores are described in units of standard deviations (SD's) above the mean value of all signals generated on that array. If targets on HuProtTM are arranged in descending order of the Z-score, the S-score is the difference (also in units of SD's) between the Z-score. S-score therefore represents the relative target specificity of a MAb to its intended target.
    A MAb is specific to its intended target if the MAb has an S-score of at least 2.5. For example, if a MAb binds to protein X with a Z-score of 43 and to protein Y with a Z-score of 14, then the S-score for the binding of that MAb to protein X is equal to 29.
  • Formalin-fixed, paraffin-embedded human gastric carcinoma tissue stained for BCMA using ab234407 at 2 μg/ml in immunohistochemical analysis.

    This data was developed using the same antibody clone in a different buffer formulation containing PBS, BSA and sodium azide (ab234407).

References

ab236326 has not yet been referenced specifically in any publications.

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