Anti-BCMA antibody - C-terminal (ab199264)
Key features and details
- Rabbit polyclonal to BCMA - C-terminal
- Suitable for: IHC-P, WB
- Reacts with: Mouse, Human
- Isotype: IgG
Overview
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Product name
Anti-BCMA antibody - C-terminal
See all BCMA primary antibodies -
Description
Rabbit polyclonal to BCMA - C-terminal -
Host species
Rabbit -
Tested applications
Suitable for: IHC-P, WBmore details -
Species reactivity
Reacts with: Mouse, Human
Predicted to work with: Rat -
Immunogen
Synthetic peptide corresponding to Human BCMA (C terminal). NP_001183.
Database link: Q02223 -
Positive control
- Skeletal Muscle (Mouse) Whole Cell Lysate (ab3869) can be used as a positive control in WB. Mouse skeletal muscle tissue lysate; Human gastric cancer tissue.
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General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle. -
Storage buffer
pH: 7.4
Preservative: 0.05% Sodium azide
Constituents: 49% PBS, 50% Glycerol (glycerin, glycerine) -
Concentration information loading...
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Purity
Immunogen affinity purified -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
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Positive Controls
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Related Products
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab199264 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
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IHC-P |
1/50 - 1/200.
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WB |
1/200 - 1/1000. Predicted molecular weight: 20 kDa.
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Notes |
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IHC-P
1/50 - 1/200. |
WB
1/200 - 1/1000. Predicted molecular weight: 20 kDa. |
Target
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Function
Receptor for TNFSF13B/BLyS/BAFF and TNFSF13/APRIL. Promotes B-cell survival and plays a role in the regulation of humoral immunity. Activates NF-kappa-B and JNK. -
Tissue specificity
Expressed in mature B-cells, but not in T-cells or monocytes. -
Involvement in disease
Note=A chromosomal aberration involving TNFRSF17 is found in a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(4;16)(q26;p13) with IL2. -
Sequence similarities
Contains 1 TNFR-Cys repeat. -
Cellular localization
Cell membrane. Endomembrane system. Perinuclear Golgi-like structures. - Information by UniProt
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Database links
- Entrez Gene: 608 Human
- Entrez Gene: 21935 Mouse
- Entrez Gene: 287034 Rat
- Omim: 109545 Human
- SwissProt: Q02223 Human
- SwissProt: O88472 Mouse
- Unigene: 2556 Human
- Unigene: 12935 Mouse
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Alternative names
- B cell maturation antigen antibody
- B cell maturation factor antibody
- B cell maturation protein antibody
see all
Images
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Immunohistochemical analysis of paraffin-embedded Human gastric cancer tissue labeling BCMA with ab199264 at 1/30 dilution.
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Anti-BCMA antibody - C-terminal (ab199264) at 1/200 dilution + Mouse skeletal muscle tissue lysate at 40 µg
Developed using the ECL technique.
Predicted band size: 20 kDa
Exposure time: 15 seconds10% SDS-PAGE
Protocols
Datasheets and documents
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SDS download
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Datasheet download
References (1)
ab199264 has been referenced in 1 publication.
- Zhan T et al. Artesunate inhibits Sjögren's syndrome-like autoimmune responses and BAFF-induced B cell hyperactivation via TRAF6-mediated NF-?B signaling. Phytomedicine 80:153381 (2021). PubMed: 33086170