Overview

  • Product name

  • Description

    Rabbit polyclonal to BCMO1
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WBmore details
  • Species reactivity

    Reacts with: Human
  • Immunogen

    Synthetic peptide corresponding to a region between C terminal amino acids 494-543 (AKSFTELARA SVDVDMHMDL HGLFITDMDW DTKKQAASEE QRDRASDCHG) of Human BCMO1 (NP_059125).

Properties

Applications

Our Abpromise guarantee covers the use of ab128370 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 62 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

Target

  • Function

    Symmetrically cleaves beta-carotene into two molecules of retinal. The reaction proceeds in three stages, epoxidation of the 15,15'-double bond, hydration of the double bond leading to ring opening, and oxidative cleavage of the diol formed.
  • Tissue specificity

    Highly expressed in retinal pigment epithelium. Also expressed in kidney, testis, liver, brain, small intestine and colon.
  • Pathway

    Cofactor metabolism; retinol metabolism.
  • Involvement in disease

    Defects in BCMO1 are the cause of autosomal dominant hypercarotenemia and vitamin A deficiency (ADHVAD) [MIM:115300]. Vitamin A is essential for normal embryonic development as well as normal physiological functions in children and adults. Hypercarotenemia is characterized by an excess carotene in the serum, but unlike excess vitamin A, carotene is non-toxic. So far, only a few cases of excess vitamin A have been reported. Individuals were thought to be vitamin A deficient due to an impairment in the conversion of carotenoids to retinal in the intestine.
  • Sequence similarities

    Belongs to the carotenoid oxygenase family.
  • Information by UniProt
  • Database links

  • Alternative names

    • BCDO antibody
    • BCDO1 antibody
    • BCDO1_HUMAN antibody
    • BCMO antibody
    • Bcmo1 antibody
    • BCO antibody
    • BCO1 antibody
    • Beta,beta-carotene 15,15'-monooxygenase antibody
    • beta-carotene 15,15'-monooxygenase 1 antibody
    • Beta-carotene dioxygenase 1 antibody
    • FLJ10730 antibody
    see all

Images

  • Anti-BCMO1 antibody (ab128370) at 1 µg/ml + A549 cell lysate

    Predicted band size: 62 kDa

References

ab128370 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

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