• Product name

  • Description

    Mouse polyclonal to BCOR
  • Host species

  • Tested applications

    Suitable for: WB, ICC/IFmore details
  • Species reactivity

    Reacts with: Human
  • Immunogen

    Recombinant full length Human BCOR (short isoform, NP_065977.1)

  • Positive control

    • Human colon tissue lysate. HeLa cells.



Our Abpromise guarantee covers the use of ab88112 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 107 kDa.
ICC/IF Use a concentration of 10 µg/ml.


  • Function

    Transcriptional corepressor. May specifically inhibit gene expression when recruited to promoter regions by sequence specific DNA-binding proteins such as BCL6 and MLLT3. This repression may be mediated at least in part by histone deacetylase activities which can associate with this corepressor. Involved in the repression of TFAP2A; impairs binding of BCL6 and KDM2B to TFAP2A promoter regions. Via repression of TFAP2A acts as a negative regulator of osteo-dentiogenic capacity in adult stem cells; the function implies inhibition of methylation on histone H3 'Lys-4' (H3K4me3) and 'Lys-36' (H3K36me2).
  • Tissue specificity

    Ubiquitously expressed.
  • Involvement in disease

    Defects in BCOR are the cause of microphthalmia syndromic type 2 (MCOPS2) [MIM:300166]. Microphthalmia is a clinically heterogeneous disorder of eye formation, ranging from small size of a single eye to complete bilateral absence of ocular tissues (anophthalmia). In many cases, microphthalmia/anophthalmia occurs in association with syndromes that include non-ocular abnormalities. MCOPS2 is a very rare multiple congenital anomaly syndrome characterized by eye anomalies (congenital cataract, microphthalmia, or secondary glaucoma), facial abnormalities (long narrow face, high nasal bridge, pointed nose with cartilages separated at the tip, cleft palate, or submucous cleft palate), cardiac anomalies (atrial septal defect, ventricular septal defect, or floppy mitral valve) and dental abnormalities (canine radiculomegaly, delayed dentition, oligodontia, persistent primary teeth, or variable root length).
  • Sequence similarities

    Belongs to the BCOR family.
    Contains 3 ANK repeats.
  • Cellular localization

  • Information by UniProt
  • Database links

  • Alternative names

    • 5830466J11Rik antibody
    • 8430401K06Rik antibody
    • ANOP 2 antibody
    • ANOP2 antibody
    • BCL 6 co repressor antibody
    • BCL 6 corepressor antibody
    • BCL 6 interacting corepressor antibody
    • BCL-6 corepressor antibody
    • BCL6 co repressor antibody
    • BCL6 corepressor antibody
    • BCL6 interacting corepressor antibody
    • BCoR antibody
    • BCOR_HUMAN antibody
    • FLJ20285 antibody
    • FLJ38041 antibody
    • KIAA1575 antibody
    • MAA 2 antibody
    • MAA2 antibody
    • MCOPS 2 antibody
    • MCOPS2 antibody
    • MGC131961 antibody
    • MGC71031 antibody
    see all


  • Anti-BCOR antibody (ab88112) at 1 µg/ml + Human colon tissue lysate at 50 µg

    Goat anti-Mouse IgG at 1/5000 dilution

    Predicted band size: 107 kDa

  • All lanes : Anti-BCOR antibody (ab88112) at 1 µg/ml

    Lane 1 : BCOR-transfected 293T cell lysate
    Lane 2 : untransfected 293T cell lysate

    Lysates/proteins at 25 µg per lane.

    All lanes : Goat anti-Mouse IgG at 1/5000 dilution

    Predicted band size: 107 kDa
    Observed band size: 110 kDa
    why is the actual band size different from the predicted?

  • Immunofluorescence staining of BCOR in HeLa cells using ab88112 at 10 µg/ml followed by a fluorescein conjugated secondary antibody.


This product has been referenced in:

  • Vewinger N  et al. IGF1R Is a Potential New Therapeutic Target for HGNET-BCOR Brain Tumor Patients. Int J Mol Sci 20:N/A (2019). Read more (PubMed: 31234291) »
  • Paret C  et al. Activation of the basal cell carcinoma pathway in a patient with CNS HGNET-BCOR diagnosis: consequences for personalized targeted therapy. Oncotarget 7:83378-83391 (2016). WB ; Human . Read more (PubMed: 27825128) »
See all 5 Publications for this product

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