Product nameAnti-BCRP/ABCG2 antibody [BXP-9]
See all BCRP/ABCG2 primary antibodies
DescriptionRat monoclonal [BXP-9] to BCRP/ABCG2
Tested applicationsSuitable for: IHC-P, ICC, IHC-Fr, WB, Flow Cytmore details
Species reactivityReacts with: Mouse
Does not react with: Human
A fusion protein containing the E. coli maltose binding protein and a fragment of the mouse bcrp protein corresponding to amino acids 221-394.
- bone marrow and kidney tissue
Storage instructionsStore at +4°C short term (1-2 weeks). Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Storage bufferPreservative: 0.1% Sodium azide
Constituent: 0.7% BSA
Serum free tissue culture supernatant
PurityTissue culture supernatant
Our Abpromise guarantee covers the use of ab24114 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|IHC-P||Use at an assay dependent concentration. PubMed: 20133811|
|ICC||1/20 - 1/50. Acetone fixed cytospin preparations|
|IHC-Fr||1/20. Fix with acetone and use biotin-streptavidin amplification.|
|WB||1/20 - 1/50. Predicted molecular weight: 70 kDa.|
|Flow Cyt||Use at an assay dependent concentration.
ab18407 - Rat monoclonal IgG1, is suitable for use as an isotype control with this antibody.
FunctionXenobiotic transporter that may play an important role in the exclusion of xenobiotics from the brain. May be involved in brain-to-blood efflux. Appears to play a major role in the multidrug resistance phenotype of several cancer cell lines. When overexpressed, the transfected cells become resistant to mitoxantrone, daunorubicin and doxorubicin, display diminished intracellular accumulation of daunorubicin, and manifest an ATP-dependent increase in the efflux of rhodamine 123.
Tissue specificityHighly expressed in placenta. Low expression in small intestine, liver and colon.
Sequence similaritiesBelongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.
Contains 1 ABC transmembrane type-2 domain.
Contains 1 ABC transporter domain.
modificationsGlycosylation-deficient ABCG2 is normally expressed and functional.
Cellular localizationCell membrane.
- Information by UniProt
- ABC transporter antibody
- ABC15 antibody
- ABCG 2 antibody
This product has been referenced in:
- Gouveia RM et al. Controlling the 3D architecture of Self-Lifting Auto-generated Tissue Equivalents (SLATEs) for optimized corneal graft composition and stability. Biomaterials 121:205-219 (2017). IF ; Human . Read more (PubMed: 28092777) »
- Lv L et al. Effect of miR-155 knockdown on the reversal of doxorubicin resistance in human lung cancer A549/dox cells. Oncol Lett 11:1161-1166 (2016). Read more (PubMed: 26893712) »