Overview

  • Product name

  • Description

    Rabbit polyclonal to BCS1L
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WBmore details
  • Species reactivity

    Reacts with: Mouse, Human
  • Immunogen

    Recombinant full length protein, corresponding to amino acids 1-419 of Human BCS1L (NP_004319.1).

  • Positive control

    • Mouse spleen tissue lysate; BCS1L transfected 293T cell line lysate

Properties

Applications

Our Abpromise guarantee covers the use of ab102808 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 - 5 µg/ml. Predicted molecular weight: 48 kDa.

Target

  • Relevance

    BCS1L (BCS1-like) is a chaperone necessary for the assembly of mitochondrial respiratory chain complex III. The protein does not contain a mitochondrial targeting sequence but experimental studies confirm that it is imported into mitochondria. Mutations in this gene are associated with mitochondrial complex III deficiency and the GRACILE syndrome. Two alternatively spliced transcripts encoding the same protein have been described.
  • Cellular localization

    Mitochondrial. Mitochondrion inner membrane. Single-pass membrane protein.
  • Database links

  • Alternative names

    • BCS 1 antibody
    • BCS 1L antibody
    • BCS antibody
    • BCS1 (yeast homolog) like antibody
    • BCS1 antibody
    • BCS1 like (S. cerevisiae) antibody
    • BCS1 like antibody
    • BCS1 like protein antibody
    • Bjornstad syndrome (pili torti and deafness) antibody
    • BJS antibody
    • FLNMS antibody
    • GRACILE antibody
    • h BCS antibody
    • H BCS1 antibody
    • Hs.6719 antibody
    • Mitochondrial chaperone BCS1 antibody
    • Mitochondrial complex III assembly antibody
    • PTD antibody
    see all

Images

  • Anti-BCS1L antibody (ab102808) at 5 µg/ml + Mouse spleen tissue lysate at 50 µg

    Secondary
    Goat anti-Mouse IgG HRP at 1/2500 dilution

    Predicted band size: 48 kDa

  • All lanes : Anti-BCS1L antibody (ab102808) at 5 µg/ml

    Lane 1 : BCS1L transfected 293T cell line lysate
    Lane 2 : Non-transfected 293T cell line lysate

    Lysates/proteins at 25 µg per lane.

    Secondary
    All lanes : Goat anti-Mouse IgG HRP at 1/2500 dilution

    Predicted band size: 48 kDa

References

This product has been referenced in:

  • Lobo-Jarne T  et al. Human COX7A2L Regulates Complex III Biogenesis and Promotes Supercomplex Organization Remodeling without Affecting Mitochondrial Bioenergetics. Cell Rep 25:1786-1799.e4 (2018). Read more (PubMed: 30428348) »
See 1 Publication for this product

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