Overview

  • Product name

    BD 1063 dihydrochloride, sigma-1 antagonist
  • Description

    Potent, selective σ-1 antagonist
  • Biological description

    Potent selective σ1 receptor antagonist (Ki values are 9 and 449 nM at σ1 and σ2 receptors, respectively). Shown to prevent hyperlocomotion, active in vivo.
  • Purity

    > 99%
  • CAS Number

    206996-13-6
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    1-[2-(3,4-Dichlorophenyl)ethyl]-4-methylpiperazine dihydrochloride
  • Molecular weight

    346.13
  • Molecular formula

    C13H18Cl2N2.2HCl
  • PubChem identifier

    11617161
  • Storage instructions

    Store at Room Temperature. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in water to 100 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    Cl.Cl.Clc2ccc(CCN1CCN(C)CC1)cc2Cl
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Hiranita T  et al. Decreases in cocaine self-administration with dual inhibition of the dopamine transporter and s receptors. J Pharmacol Exp Ther 339:662-77 (2011). Read more (PubMed: 21859929) »
  • Sabino V  et al. The sigma-receptor antagonist BD-1063 decreases ethanol intake and reinforcement in animal models of excessive drinking. Neuropsychopharmacology 34:1482-93 (2009). Read more (PubMed: 18946467) »
  • McCracken KA  et al. Novel sigma receptor ligands attenuate the locomotor stimulatory effects of cocaine. Eur J Pharmacol 365:35-8 (1999). Read more (PubMed: 9988120) »

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