Overview

  • Product name

    Anti-BDNF antibody [BS375]
    See all BDNF primary antibodies
  • Description

    Mouse monoclonal [BS375] to BDNF
  • Host species

    Mouse
  • Tested applications

    Suitable for: Flow Cytmore details
  • Species reactivity

    Reacts with: Human
  • Immunogen

    Synthetic peptide corresponding to Human BDNF aa 47-58.
    Sequence:

    C-NGPKAGSRGLTS


    Database link: P23560

  • Positive control

    • Flow Cyt: SH-SY5Y cells.

Properties

Applications

Our Abpromise guarantee covers the use of ab228505 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
Flow Cyt Use 2µl for 106 cells.

Target

  • Function

    During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including long-term potentiation (LTP), long-term depression (LTD), certain forms of short-term synaptic plasticity, as well as homeostatic regulation of intrinsic neuronal excitability.
  • Tissue specificity

    Brain. Highly expressed in hippocampus, amygdala, cerebral cortex and cerebellum. Also expressed in heart, lung, skeletal muscle, testis, prostate and placenta.
  • Involvement in disease

    Bulimia nervosa 2
    Congenital central hypoventilation syndrome
  • Sequence similarities

    Belongs to the NGF-beta family.
  • Post-translational
    modifications

    The propeptide is N-glycosylated and glycosulfated.
    Converted into mature BDNF by plasmin (PLG).
  • Cellular localization

    Secreted.
  • Information by UniProt
  • Database links

  • Alternative names

    • Abrineurin antibody
    • ANON2 antibody
    • BDNF antibody
    • BDNF_HUMAN antibody
    • Brain Derived Neurotrophic Factor antibody
    • Brain-derived neurotrophic factor antibody
    • BULN2 antibody
    • MGC34632 antibody
    • Neurotrophin antibody
    see all

Images

  • Flow cytometric analysis of methanol-fixed (10 minutes on ice), 0.1% Tween-20-permeabilized SH-SY5Y (human neuroblastoma cell line from bone marrow) cells labeling BDNF with ab228505 at 2 µg per 106 cells (black) compared with a Rabbit IgG Control (white). Goat anti-Mouse PE at 1/100 dilution was used as the secondary antibody.

References

ab228505 has not yet been referenced specifically in any publications.

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