Anti-BDNF antibody [EPR1292] (ab108319)

Rabbit recombinant monoclonal BDNF antibody [EPR1292]. Validated in WB, IHC, Flow Cyt, ICC/IF and tested in Mouse, Rat, Human. Cited in 62 publication(s). Independently reviewed in 4 review(s).

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ab108319 has been referenced in 66 publications.

  • Starowicz G  et al. Long-lasting antidepressant-like activity of the GPR39 zinc receptor agonist TC-G 1008. J Affect Disord 245:325-334 (2019). PubMed: 30419533
  • Huang L  et al. Irisin regulates the expression of BDNF and glycometabolism in diabetic rats. Mol Med Rep 19:1074-1082 (2019). PubMed: 30569121
  • Manoukian OS  et al. Aligned microchannel polymer-nanotube composites for peripheral nerve regeneration: Small molecule drug delivery. J Control Release 296:54-67 (2019). PubMed: 30658124
  • Stajic D  et al. The role of galectin-3 in modulation of anxiety state level in mice. Brain Behav Immun N/A:N/A (2019). PubMed: 30682502
  • Li J  et al. Chronic mild corticosterone exposure during adolescence enhances behaviors and upregulates neuroplasticity-related proteins in rat hippocampus. Prog Neuropsychopharmacol Biol Psychiatry 89:400-411 (2019). PubMed: 30392783
  • Han X  et al. Metformin Modulates High Glucose-Incubated Human Umbilical Vein Endothelial Cells Proliferation and Apoptosis Through AMPK/CREB/BDNF Pathway. Front Pharmacol 9:1266 (2018). PubMed: 30459620
  • Kim YR  et al. Antidepressant Effect of Fraxinus rhynchophylla Hance Extract in a Mouse Model of Chronic Stress-Induced Depression. Biomed Res Int 2018:8249563 (2018). PubMed: 30065945
  • Liu L  et al. Hippocampal Mechanisms Underlying Impairment in Spatial Learning Long After Establishment of Noise-Induced Hearing Loss in CBA Mice. Front Syst Neurosci 12:35 (2018). PubMed: 30087600
  • Zhang YP  et al. Mifepristone attenuates depression-like changes induced by chronic central administration of interleukin-1ß in rats. Behav Brain Res 347:436-445 (2018). PubMed: 29580890
  • Hou L  et al. Synaptic Ultrastructure Might Be Involved in HCN1-Related BDNF mRNA in Withdrawal-Anxiety After Ethanol Dependence. Front Psychiatry 9:215 (2018). PubMed: 29896126
  • Zhang J  et al. Jia-Jian-Di-Huang-Yin-Zi decoction exerts neuroprotective effects on dopaminergic neurons and their microenvironment. Sci Rep 8:9886 (2018). PubMed: 29959371
  • Zhang C  et al. Minocycline ameliorates depressive behaviors and neuro-immune dysfunction induced by chronic unpredictable mild stress in the rat. Behav Brain Res 356:348-357 (2018). PubMed: 30003978
  • Gao JY  et al. Depressive- and anxiety-like phenotypes in young adult APPSwe/PS1dE9 transgenic mice with insensitivity to chronic mild stress. Behav Brain Res 353:114-123 (2018). PubMed: 30012417
  • Lv C  et al. Long-Term DL-3-n-Butylphthalide Treatment Alleviates Cognitive Impairment Correlate With Improving Synaptic Plasticity in SAMP8 Mice. Front Aging Neurosci 10:200 (2018). PubMed: 30026693
  • Yu J  et al. IL-1ß Stimulates Brain-Derived Neurotrophic Factor Production in Eutopic Endometriosis Stromal Cell Cultures: A Model for Cytokine Regulation of Neuroangiogenesis. Am J Pathol 188:2281-2292 (2018). PubMed: 30031725
  • Fu F  et al. NDUFA4 enhances neuron growth by triggering growth factors and inhibiting neuron apoptosis through Bcl-2 and cytochrome C mediated signaling pathway. Am J Transl Res 10:164-174 (2018). PubMed: 29423002
  • Sutton LP  et al. Orphan receptor GPR158 controls stress-induced depression. Elife 7:N/A (2018). PubMed: 29419376
  • Lei D  et al. Synergistic neuroprotective effect of rasagiline and idebenone against retinal ischemia-reperfusion injury via the Lin28-let-7-Dicer pathway. Oncotarget 9:12137-12153 (2018). PubMed: 29552298
  • Tu WZ  et al. Effect of electro-acupuncture on the BDNF-TrkB pathway in the spinal cord of CCI rats. Int J Mol Med 41:3307-3315 (2018). PubMed: 29568892
  • Li X  et al. Apocynum venetum leaf extract reverses depressive-like behaviors in chronically stressed rats by inhibiting oxidative stress and apoptosis. Biomed Pharmacother 100:394-406 (2018). ICC/IF . PubMed: 29454288
  • Zhang Y  et al. nNOS-CAPON interaction mediates amyloid-ß-induced neurotoxicity, especially in the early stages. Aging Cell 17:e12754 (2018). PubMed: 29577585
  • Pedard M  et al. Vascular brain-derived neurotrophic factor pathway in rats with adjuvant-induced arthritis: Effect of anti-rheumatic drugs. Atherosclerosis 274:77-85 (2018). PubMed: 29753231
  • Jorge-Torres OC  et al. Inhibition of Gsk3b Reduces Nfkb1 Signaling and Rescues Synaptic Activity to Improve the Rett Syndrome Phenotype in Mecp2-Knockout Mice. Cell Rep 23:1665-1677 (2018). IHC ; Mouse . PubMed: 29742424
  • Brague JC  et al. BDNF infusion into the MPN mag is sufficient to restore copulatory behavior in the castrated Syrian hamster. Horm Behav 102:69-75 (2018). WB . PubMed: 29750970
  • Wu GF  et al. Antidepressant effect of taurine in chronic unpredictable mild stress-induced depressive rats. Sci Rep 7:4989 (2017). WB . PubMed: 28694433
  • Guo Y  et al. Jisuikang, a Chinese herbal formula, increases neurotrophic factor expression and promotes the recovery of neurological function after spinal cord injury. Neural Regen Res 12:1519-1528 (2017). IHC-P ; Rat . PubMed: 29089999
  • Zhang XL  et al. Timosaponin B-III exhibits antidepressive activity in a mouse model of postpartum depression by the regulation of inflammatory cytokines, BNDF signaling and synaptic plasticity. Exp Ther Med 14:3856-3861 (2017). PubMed: 29042992
  • Einoch R  et al. The involvement of BDNF-CREB signaling pathways in the pharmacological mechanism of combined SSRI- antipsychotic treatment in schizophrenia. Eur Neuropsychopharmacol 27:470-483 (2017). PubMed: 28410959
  • Liu Q  et al. Effects of co-administration of ketamine and ethanol on the dopamine system via the cortex-striatum circuitry. Life Sci 179:1-8 (2017). PubMed: 28454718
  • Xiao L  et al. Human Dental Pulp Cells Differentiate toward Neuronal Cells and Promote Neuroregeneration in Adult Organotypic Hippocampal Slices In Vitro. Int J Mol Sci 18:N/A (2017). PubMed: 28800076
  • Zhao H  et al. Anti-depressant-like effects of Jieyu chufan capsules in a mouse model of unpredictable chronic mild stress. Exp Ther Med 14:1086-1094 (2017). PubMed: 28810562
  • Na ES  et al. D-cycloserine improves synaptic transmission in an animal mode of Rett syndrome. PLoS One 12:e0183026 (2017). PubMed: 28813484
  • Portbury SD  et al. Trehalose improves traumatic brain injury-induced cognitive impairment. PLoS One 12:e0183683 (2017). PubMed: 28837626
  • Lin JG  et al. Electroacupuncture Promotes Recovery of Motor Function and Reduces Dopaminergic Neuron Degeneration in Rodent Models of Parkinson's Disease. Int J Mol Sci 18:N/A (2017). PubMed: 28837077
  • Lin R  et al. Electro-acupuncture ameliorates cognitive impairment via improvement of brain-derived neurotropic factor-mediated hippocampal synaptic plasticity in cerebral ischemia-reperfusion injured rats. Exp Ther Med 14:2373-2379 (2017). PubMed: 28962170
  • Chen G  et al. Risperidone reverses the spatial object recognition impairment and hippocampal BDNF-TrkB signalling system alterations induced by acute MK-801 treatment. Biomed Rep 6:285-290 (2017). WB ; Rat . PubMed: 28451387
  • Gideons ES  et al. Chronic lithium treatment elicits its antimanic effects via BDNF-TrkB dependent synaptic downscaling. Elife 6:N/A (2017). Mouse . PubMed: 28621662
  • Wang TY  et al. Expression profiles and function analysis of microRNAs in postovulatory aging mouse oocytes. Aging (Albany NY) 9:1186-1201 (2017). WB . PubMed: 28394765
  • Li J  et al. Differential Behavioral and Neurobiological Effects of Chronic Corticosterone Treatment in Adolescent and Adult Rats. Front Mol Neurosci 10:25 (2017). WB . PubMed: 28210212
  • Su ZY  et al. Dexmedetomidine mitigates isoflurane-induced neurodegeneration in fetal rats during the second trimester of pregnancy. Neural Regen Res 12:1329-1337 (2017). IHC-P ; Rat . PubMed: 28966649
  • Xu LZ  et al. BDNF-GSK-3ß-ß-Catenin Pathway in the mPFC Is Involved in Antidepressant-Like Effects of Morinda officinalis Oligosaccharides in Rats. Int J Neuropsychopharmacol 20:83-93 (2017). PubMed: 27729466
  • Liu F  et al. Antidepressant effect of recombinant NT4-NAP/AAV on social isolated mice through intranasal route. Oncotarget 8:10103-10113 (2017). PubMed: 28052034
  • Jichao S  et al. Saikosaponin A Alleviates Symptoms of Attention Deficit Hyperactivity Disorder through Downregulation of DAT and Enhancing BDNF Expression in Spontaneous Hypertensive Rats. Evid Based Complement Alternat Med 2017:2695903 (2017). PubMed: 28293263
  • Pedard M  et al. The Cerebral Brain-Derived Neurotrophic Factor Pathway, Either Neuronal or Endothelial, Is Impaired in Rats with Adjuvant-Induced Arthritis. Connection with Endothelial Dysfunction. Front Physiol 8:1125 (2017). PubMed: 29375397
  • Wang B  et al. Neurotrophin expression and laryngeal muscle pathophysiology following recurrent laryngeal nerve transection. Mol Med Rep 13:1234-42 (2016). PubMed: 26677138
  • Lin R  et al. Electroacupuncture at the Baihui acupoint alleviates cognitive impairment and exerts neuroprotective effects by modulating the expression and processing of brain-derived neurotrophic factor in APP/PS1 transgenic mice. Mol Med Rep 13:1611-7 (2016). PubMed: 26739187
  • Shi N  et al. Rehabilitation Training and Resveratrol Improve the Recovery of Neurological and Motor Function in Rats after Cerebral Ischemic Injury through the Sirt1 Signaling Pathway. Biomed Res Int 2016:1732163 (2016). PubMed: 28116292
  • Zhang XQ  et al. Increased protein expression levels of pCREB, BDNF and SDF-1/CXCR4 in the hippocampus may be associated with enhanced neurogenesis induced by environmental enrichment. Mol Med Rep 14:2231-7 (2016). PubMed: 27432087
  • Monnier A  et al. Brain-derived neurotrophic factor of the cerebral microvasculature: a forgotten and nitric oxide-dependent contributor of brain-derived neurotrophic factor in the brain. Acta Physiol (Oxf) N/A:N/A (2016). Rat . PubMed: 27364224
  • Liu T  et al. Cannabinoid-Elicited Conditioned Place Preference in a Modified Behavioral Paradigm. Biol Pharm Bull 39:747-53 (2016). WB ; Rat . PubMed: 26935020
  • Rogers J  et al. Dissociating the therapeutic effects of environmental enrichment and exercise in a mouse model of anxiety with cognitive impairment. Transl Psychiatry 6:e794 (2016). WB ; Mouse . PubMed: 27115125
  • Yu JW  et al. Synergistic and Superimposed Effect of Bone Marrow-Derived Mesenchymal Stem Cells Combined with Fasudil in Experimental Autoimmune Encephalomyelitis. J Mol Neurosci N/A:N/A (2016). PubMed: 27573128
  • Xu H  et al. Effects of Duloxetine Treatment on Cognitive Flexibility and BDNF Expression in the mPFC of Adult Male Mice Exposed to Social Stress during Adolescence. Front Mol Neurosci 9:95 (2016). WB ; Mouse . PubMed: 27757074
  • Cao G  et al. Xiao Yao San against Corticosterone-Induced Stress Injury via Upregulating Glucocorticoid Receptor Reaction Element Transcriptional Activity. Evid Based Complement Alternat Med 2016:5850739 (2016). PubMed: 27822288
  • Dong XZ  et al. Kai-Xin-San, a traditional Chinese medicine formulation, exerts antidepressive and neuroprotective effects by promoting pCREB upstream pathways. Exp Ther Med 12:3308-3314 (2016). WB ; Rat . PubMed: 27882154
  • Wei YB  et al. Telomerase dysregulation in the hippocampus of a rat model of depression: normalization by lithium. Int J Neuropsychopharmacol 18:pyv002 (2015). PubMed: 25618407
  • Gideons ES  et al. Mechanisms underlying differential effectiveness of memantine and ketamine in rapid antidepressant responses. Proc Natl Acad Sci U S A 111:8649-54 (2014). PubMed: 24912158
  • Wei Y  et al. Antidepressant-like effect of sodium butyrate is associated with an increase in TET1 and in 5-hydroxymethylation levels in the Bdnf gene. Int J Neuropsychopharmacol 18:N/A (2014). PubMed: 25618518
  • Rodier M  et al. Exogenous t-PA administration increases hippocampal mature BDNF levels. plasmin- or NMDA-dependent mechanism? PLoS One 9:e92416 (2014). WB ; Rat . PubMed: 24670989
  • Banoujaafar H  et al. Brain BDNF levels elevation induced by physical training is reduced after unilateral common carotid artery occlusion in rats. J Cereb Blood Flow Metab N/A:N/A (2014). WB ; Rat . PubMed: 25052557
  • Lavezzi AM  et al. Disruption of the brain-derived neurotrophic factor (BDNF) immunoreactivity in the human Kölliker-Fuse nucleus in victims of unexplained fetal and infant death. Front Hum Neurosci 8:648 (2014). IHC-P ; Human . PubMed: 25237300
  • Bifsha P  et al. Rgs6 is required for adult maintenance of dopaminergic neurons in the ventral substantia nigra. PLoS Genet 10:e1004863 (2014). IHC-P ; Mouse . PubMed: 25501001
  • Chavez-Valdez R  et al. Sexual dimorphism in BDNF signaling after neonatal hypoxia-ischemia and treatment with necrostatin-1. Neuroscience 260:106-19 (2014). WB ; Mouse . PubMed: 24361177
  • Quirié A  et al. Effect of stroke on arginase expression and localization in the rat brain. Eur J Neurosci 37:1193-202 (2013). Rat . PubMed: 23311438
  • Quirié A  et al. Comparative effect of treadmill exercise on mature BDNF production in control versus stroke rats. PLoS One 7:e44218 (2012). WB, IHC-FoFr ; Rat . PubMed: 22962604
  • Madinier A  et al. Ipsilateral versus contralateral spontaneous post-stroke neuroplastic changes: Involvement of BDNF? Neuroscience : (2012). WB . PubMed: 23219910


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