Overview

  • Product name

    BEC, Arginase inhibitor
  • Description

    Potent, slow binding, competitive arginase inhibitor
  • Biological description

    Potent, slow binding, competitive arginase inhibitor (Ki values are 30 and 500 nM for human arginase II and rat arginase I respectively). Enhances NO-dependent smooth muscle relaxation. Shows pro-inflammatory effects in vivo. Orally active.
  • Purity

    > 98%
  • CAS Number

    63107-40-4
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    (2R)-2-Amino-3-(2-boronoethylsulfanyl)propanoic acid
  • Molecular weight

    193.03
  • Molecular formula

    C5H12BNO4S
  • PubChem identifier

    9877608
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in PBS (pH 7.2) to 25 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    B(CCSC[C@@H](C(=O)O)N)(O)O
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Jiang W  et al. Arginase inhibition protects against hypoxia-induced pulmonary arterial hypertension. Mol Med Rep 12:4743-9 (2015). Read more (PubMed: 26126810) »
  • Kim SH  et al. Helicobacter pylori arginase mutant colonizes arginase II knockout mice. World J Gastroenterol 17:3300-9 (2011). Read more (PubMed: 21876618) »
  • Ckless K  et al. Inhibition of arginase activity enhances inflammation in mice with allergic airway disease, in association with increases in protein S-nitrosylation and tyrosine nitration. J Immunol 181:4255-64 (2008). Read more (PubMed: 18768883) »

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Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
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