Becatecarin, Topoisomerase II inhibitor (ab144204)

Overview

  • Product name
    Becatecarin, Topoisomerase II inhibitor
  • Description
    Topoisomerase II inhibitor. DNA intercalating agent.
  • Biological description
    Topoisomerase II inhibitor. DNA intercalating agent. Rebeccamycin (ab144341) analog. ABCG2 transport substrate. Shows antitumor effects in vivo.
  • Purity
    > 98%

Properties

  • Chemical name
    1,11-Dichloro-6-(2-(diethylamino)ethyl)-12,13-dihydro-12-(4-O-methyl-beta-D-glucopyranosyl)-5H-indolo(2,3-a)pyrrolo(3,4-c)carbazole-5,7(6H)-dione
  • Molecular weight
    669.55
  • Chemical structure
    Chemical Structure
  • Molecular formula
    C33H34Cl2N4O7
  • CAS Number
    119673-08-4
  • PubChem identifier
    101524
  • Storage instructions
    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview
    Soluble in DMSO
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES
    CCN(CC)CCN1C(=O)C2=C3C4=C(C(=CC=C4)Cl)NC3=C5C(=C2C1=O)C6=C(N5[C@H]7[C@@H]([C@H]([C@@H]([C@H](O7)CO)OC)O)O)C(=CC=C6)Cl
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:
  • Robey RW  et al. Becatecarin (rebeccamycin analog, NSC 655649) is a transport substrate and induces expression of the ATP-binding cassette transporter, ABCG2, in lung carcinoma cells. Cancer Chemother Pharmacol 64:575-83 (2009). Read more (PubMed: 19132374) »
  • Long BH  et al. Discovery of antitumor indolocarbazoles: rebeccamycin, NSC 655649, and fluoroindolocarbazoles. Curr Med Chem Anticancer Agents 2:255-66 (2002). Read more (PubMed: 12678746) »
  • Krishnan BS  et al. Fluorescence polarization studies of the binding of BMS 181176 to DNA. J Biomol Struct Dyn 12:625-36 (1994). Read more (PubMed: 7727062) »

Customer reviews and Q&As

Question
Answer

The purity was determined by HPLC.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"

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