Overview

  • Product name
    Bemegride
  • Description
    GABAA receptor antagonist
  • Biological description
    GABAA receptor antagonist. Increases tidal volume and respiration via central nervous system stimulation and induces convulsions in vivo.
  • Purity
    > 99%

Properties

  • Chemical name
    4-Ethyl-4-methylpiperidine-2,6-dione
  • Molecular weight
    155.19
  • Chemical structure
    Chemical Structure
  • Molecular formula
    C8H13NO2
  • CAS Number
    64-65-3
  • PubChem identifier
    2310
  • Storage instructions
    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview
    Soluble in ethanol to 100 mM and in DMSO to 100 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Toxic, refer to SDS for further information.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES
    CCC1(CC(=O)NC(=O)C1)C
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:
  • Gonzalez LA  et al. Carisoprodol-mediated modulation of GABAA receptors: in vitro and in vivo studies. J Pharmacol Exp Ther 329:827-37 (2009). Read more (PubMed: 19244096) »
  • Mistry DK & Cottrell GA Actions of steroids and bemegride on the GABAA receptor of mouse spinal neurones in culture. Exp Physiol 75:199-209 (1990). Read more (PubMed: 2160252) »
  • Shearman G & Lal H Discriminative stimulus properties of pentylenetetrazol and bemegride: some generalization and antagonism tests. Psychopharmacology (Berl) 64:315-9 (1979). Read more (PubMed: 41279) »

See 0 Publications for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"

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