GABAA receptor antagonist. Increases tidal volume and respiration via central nervous system stimulationand induces convulsions in vivo.
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
Soluble in ethanol to 100 mM and in DMSO to 100 mM
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
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Mistry DK & Cottrell GA Actions of steroids and bemegride on the GABAA receptor of mouse spinal neurones in culture. Exp Physiol75:199-209 (1990).
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Shearman G & Lal H Discriminative stimulus properties of pentylenetetrazol and bemegride: some generalization and antagonism tests. Psychopharmacology (Berl)64:315-9 (1979).
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