Overview

  • Product name

    Bemegride, GABAA receptor antagonist
  • Description

    GABAA receptor antagonist
  • Biological description

    GABAA receptor antagonist. Increases tidal volume and respiration via central nervous system stimulation and induces convulsions in vivo.
  • Purity

    > 99%
  • CAS Number

    64-65-3
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    4-Ethyl-4-methylpiperidine-2,6-dione
  • Molecular weight

    155.19
  • Molecular formula

    C8H13NO2
  • PubChem identifier

    2310
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in ethanol to 100 mM and in DMSO to 100 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Toxic, refer to SDS for further information.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CCC1(CC(=O)NC(=O)C1)C
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Gonzalez LA  et al. Carisoprodol-mediated modulation of GABAA receptors: in vitro and in vivo studies. J Pharmacol Exp Ther 329:827-37 (2009). Read more (PubMed: 19244096) »
  • Mistry DK & Cottrell GA Actions of steroids and bemegride on the GABAA receptor of mouse spinal neurones in culture. Exp Physiol 75:199-209 (1990). Read more (PubMed: 2160252) »
  • Shearman G & Lal H Discriminative stimulus properties of pentylenetetrazol and bemegride: some generalization and antagonism tests. Psychopharmacology (Berl) 64:315-9 (1979). Read more (PubMed: 41279) »

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