Overview

  • Product name

    Benazepril hydrochloride, Angiotensin-converting enzyme (ACE) inhibitor
  • Description

    Angiotensin-converting enzyme (ACE) inhibitor. Prodrug.
  • Biological description

    Angiotensin-converting enzyme (ACE) inhibitor (IC50 = 0.27 nM). Prodrug. Orally active in vivo. Antihypertensive. Minimal ability to cross the blood-brain barrier.
  • Purity

    > 99%
  • CAS Number

    86541-74-4
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    3-[[(1S)-1-(Ethoxycarbonyl)-3-phenylpropyl]amino]-2,3,4,5-tetrahydro-2-oxo-1H-1-benzazepine-1-acetic acid hydrochloride
  • Molecular weight

    460.96
  • Molecular formula

    C24H28N2O5.HCl
  • PubChem identifier

    5362123
  • Storage instructions

    Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in water to 25 mM, in ethanol to 100 mM and in DMSO to 100 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    Cl.O=C(OCC)C(CCc1ccccc1)NC3CCc2ccccc2N(CC(=O)O)C3=O
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • King JN  et al. Pharmacokinetic/pharmacodynamic modelling of the disposition and effect of benazepril and benazeprilat in cats. J Vet Pharmacol Ther 26:213-24 (2003). Read more (PubMed: 12755906) »
  • Toutain PL  et al. Benazeprilat disposition and effect in dogs revisited with a pharmacokinetic/pharmacodynamic modeling approach. J Pharmacol Exp Ther 292:1087-93 (2000). Read more (PubMed: 10688627) »
  • Balfour JA & Goa KL Benazepril. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy in hypertension and congestive heart failure. Drugs 42:511-39 (1991). Read more (PubMed: 1720384) »
  • Waldmeier F & Schmid K Disposition of [14C]-benazepril hydrochloride in rat, dog and baboon. Absorption, distribution, kinetics, biotransformation and excretion. Arzneimittelforschung 39:62-7 (1989). Read more (PubMed: 2719745) »

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