Benfotiamine, vitamin B1 analogue (ab142831)

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Overview

  • Product name

    Benfotiamine, vitamin B1 analogue

  • Description

    Vitamin B1 analogue. Potent anti-oxidant.

  • Biological description

    Vitamin B1 analogue. Potent anti-oxidant. Increases thiamine levels in plasma, erythrocytes and liver cells with greater potency than vitamin B1 (ab143348). Shows antineuropathic effects in vivo. Orally active.

  • Purity

    > 98%

  • CAS Number

    22457-89-2

  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    S-[2-[(4-Amino-2-methylpyrimidin-5-yl)methyl-formylamino]-5-phosphonooxypent-2-en-3-yl] benzenecarbothioate

  • Molecular weight

    466.45

  • Molecular formula

    C19H23N4O6PS

  • PubChem identifier

    2320

  • Storage instructions

    Store at Room Temperature. The product can be stored for up to 12 months.

  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CC1=NC=C(C(=N1)N)CN(C=O)C(=C(CCOP(=O)(O)O)SC(=O)C2=CC=CC=C2)C

  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Portari GV  et al. Liver, plasma and erythrocyte levels of thiamine and its phosphate esters in rats with acute ethanol intoxication: a comparison of thiamine and benfotiamine administration. Eur J Pharm Sci 48:799-802 (2013). Read more (PubMed: 23369791) »
  • Shoeb M & Ramana KV Anti-inflammatory effects of benfotiamine are mediated through the regulation of the arachidonic acid pathway in macrophages. Free Radic Biol Med 52:182-90 (2012). Read more (PubMed: 22067901) »
  • Hurt JK  et al. Prostatic acid phosphatase is required for the antinociceptive effects of thiamine and benfotiamine. PLoS One 7:e48562 (2012). Read more (PubMed: 23119057) »

Publishing research using ab142831? Please let us know so that we can cite the reference in this datasheet.

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