Benzo[a]pyrene (B[a]P), Mutagenic agent (ab142566)
- Datasheet
- References
Overview
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Product name
Benzo[a]pyrene (B[a]P), Mutagenic agent -
Description
Mutagenic agent -
Alternative names
- B[a]P
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Biological description
Mutagenic agent. Inhibits EROD activtiy (IC50 values are 31, 140 and 350 nM at P450 1B1, 1A2 and 1A1 respectively). Causes DNA adducts in vivo. Upregulates the expression of HPV E7oncoprotein. Orally active. -
Purity
> 98% -
CAS Number
50-32-8 -
Chemical structure
Properties
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Chemical name
Benzo[a]pyrene -
Molecular weight
252.32 -
Molecular formula
C20H12 -
PubChem identifier
2336 -
Storage instructions
Store at Room Temperature. The product can be stored for up to 12 months. -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
C1=CC=C2C3=C4C(=CC2=C1)C=CC5=C4C(=CC=C5)C=C3 -
Source
Synthetic
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Research areas
References
This product has been referenced in:
- Rajendran P et al. Immunomodulatory Effect of Mangiferin in Experimental Animals with Benzo(a)Pyrene-induced Lung Carcinogenesis. Int J Biomed Sci 9:68-74 (2013). Read more (PubMed: 23847456) »
- Rossner P et al. Nucleotide excision repair is not induced in human embryonic lung fibroblasts treated with environmental pollutants. PLoS One 8:e69197 (2013). Read more (PubMed: 23894430) »
- Maher DM et al. Curcumin suppresses human papillomavirus oncoproteins, restores p53, Rb, and PTPN13 proteins and inhibits benzo[a]pyrene-induced upregulation of HPV E7. Mol Carcinog 50:47-57 (2011). Read more (PubMed: 21061268) »
