Overview

  • Product name

    Bepotastine Besilate, H1 receptor antagonist
  • Description

    Selective H1 receptor antagonist
  • Biological description

    Selective H1 receptor antagonist. Stabilizes mast cell function. Inhibits eosinophilic infiltration. Inhibits IL-5 production, LTB4 and LTD4 activity. Shows antiallergic and antipruritic effects in vivo. Orally active.
  • Purity

    > 99%
  • CAS Number

    190786-44-8
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    4-[4-[(S)-(4-Chlorophenyl)-pyridin-2-ylmethoxy]piperidin-1-yl]butanoic acid besilate
  • Molecular weight

    547.06
  • Molecular formula

    C21H25ClN2O3.C6H6O3S
  • PubChem identifier

    164521
  • Storage instructions

    Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in DMSO to 100 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    N1(CCC(CC1)O[C@H](C2C=CC=CN=2)C3C=CC(=CC=3)Cl)CCCC(=O)O.C4=CC(=CC=C4)S(O)(=O)=O
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Kida T  et al. Bepotastine besilate, a highly selective histamine H(1) receptor antagonist, suppresses vascular hyperpermeability and eosinophil recruitment in in vitro and in vivo experimental allergic conjunctivitis models. Exp Eye Res 91:85-91 (2010). Read more (PubMed: 20412793) »
  • Williams JI  et al. Non-clinical pharmacology, pharmacokinetics, and safety findings for the antihistamine bepotastine besilate. Curr Med Res Opin 26:2329-38 (2010). Read more (PubMed: 20735291) »
  • Tanizaki H  et al. Oral administration of bepotastine besilate suppressed scratching behavior of atopic dermatitis model NC/Nga mice. Int Arch Allergy Immunol 145:277-82 (2008). Read more (PubMed: 18004068) »

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