Overview

  • Product name

    Berbamine dihydrochloride, NF-kappaB inhibitor
  • Description

    NF-κB inhibitor. Potent antitumor agent.
  • Biological description

    NF-κB inhibitor. Potent antitumor agent. Inhibits Bcr-Abl signaling in blood cancers. Shows antiproliferative effects, induces G1 phase arrest and apoptosis. Downregulates IKKα and p-IκBα expression. Increases A20 expression. Inhibits p65 nuclear localization.
  • Purity

    > 98%
  • CAS Number

    6078-17-7
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    6,6',7-Trimethoxy-2,2'-dimethylberbaman-12-ol dihydrochloride
  • Molecular weight

    681.65
  • Molecular formula

    C37H40N2O6.2HCl
  • PubChem identifier

    16217067
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in ethanol and in DMSO to 100 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CN1CCC2=CC(=C3C=C2C1CC4=CC=C(C=C4)OC5=C(C=CC(=C5)CC6C7=C(O3)C(=C(C=C7CCN6C)OC)OC)O)OC.Cl.Cl
  • Source

    Berberis amurensis

  • Research areas

References

This product has been referenced in:

  • Campisi A  et al. Antioxidant properties of Berberis aetnensis C. Presl (Berberidaceae) roots extract and protective effects on astroglial cell cultures. ScientificWorldJournal 2014:315473 (2014). Read more (PubMed: 25177720) »
  • Nam S  et al. Novel synthetic derivatives of the natural product berbamine inhibit Jak2/Stat3 signaling and induce apoptosis of human melanoma cells. Mol Oncol 6:484-93 (2012). Read more (PubMed: 22717603) »
  • Liang Y  et al. Berbamine, a novel nuclear factor kappaB inhibitor, inhibits growth and induces apoptosis in human myeloma cells. Acta Pharmacol Sin 30:1659-65 (2009). Read more (PubMed: 19960011) »

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