Bestatin methyl ester, neutral aminopeptidase inhibitor (ab145909)

Overview

  • Product name

    Bestatin methyl ester, neutral aminopeptidase inhibitor
  • Description

    Cell-permeable derivative of Bestatin (ab141417); neutral aminopeptidase inhibitor.
  • Alternative names

    • (-)-N-[(2S, 3R)-3-Amino-2-hydroxy-4-phenylbutyryl]-L-leucine Methyl Ester
    • BME
    • Methyl Bestatin
  • Biological description

    Cell-permeable derivative of Bestatin (ab141417). Displays slightly stronger inhibition of neutral aminopeptidase than Bestatin but has much weaker activity against basic aminopeptidase. Augments Fas- or TNF-α-induced apoptosis in solid tumor cell lines.

  • Purity

    > 97%
  • CAS Number

    65322-89-6
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    (-)-N-[(2S, 3R)-3-Amino-2-hydroxy-4-phenylbutyryl]-L-leucine methyl ester
  • Molecular weight

    322.40
  • Molecular formula

    C17H26N2O4
  • Storage instructions

    Store at +4°C. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in DMSO
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • Source

    Synthetic

References

This product has been referenced in:

  • Poloz Y  et al. Bestatin inhibits cell growth, cell division, and spore cell differentiation in Dictyostelium discoideum. Eukaryot Cell 11:545-57 (2012). Read more (PubMed: 22345351) »
  • Sekine K  et al. Augmentation of death ligand-induced apoptosis by aminopeptidase inhibitors in human solid tumor cell lines. Int J Cancer 94:485-91 (2001). Read more (PubMed: 11745433) »
  • Sekine K  et al. Induction of apoptosis by bestatin (ubenimex) in human leukemic cell lines. Leukemia 13:729-34 (1999). Read more (PubMed: 10374877) »

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Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
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