Product nameAnti-beta 2 Microglobulin antibody
See all beta 2 Microglobulin primary antibodies
DescriptionRabbit polyclonal to beta 2 Microglobulin
Tested applicationsSuitable for: WB, IP, ELISA, Conjugation, Dot blot, ICC/IFmore details
Species reactivityReacts with: Human
b 2-Microglobulin [Human Urine]
General notesThe antibody reacts with b2-microglobulin isolated from human urine showing a 12.8 kDa band under non-reducing condition of SDS-PAGE.
Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
Storage bufferpH: 7.20
Preservative: 0.01% Sodium azide
Constituents: 0.878% Sodium chloride, 0.424% Potassium phosphate
Concentration information loading...
Purification notesThis product is an IgG fraction antibody purified from monospecific antiserum by a multi-step process which includes delipidation, salt fractionation and ion exchange chromatography followed by extensive dialysis against the buffer stated above. Assay by immunoelectrophoresis resulted in a single precipitin arc against anti-Rabbit Serum as well as purified and partially purified b 2-Microglobulin [Human Urine].
Our Abpromise guarantee covers the use of ab6608 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|WB||Use at an assay dependent concentration.|
|IP||Use at an assay dependent concentration.|
|ELISA||Use at an assay dependent concentration.|
|Conjugation||Use at an assay dependent concentration.|
|Dot blot||Use at an assay dependent concentration.|
|ICC/IF||Use at an assay dependent concentration. PubMed: 20017200|
FunctionComponent of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.
Involvement in diseaseDefects in B2M are the cause of hypercatabolic hypoproteinemia (HYCATHYP) [MIM:241600]. Affected individuals show marked reduction in serum concentrations of immunoglobulin and albumin, probably due to rapid degradation.
Note=Beta-2-microglobulin may adopt the fibrillar configuration of amyloid in certain pathologic states. The capacity to assemble into amyloid fibrils is concentration dependent. Persistently high beta(2)-microglobulin serum levels lead to amyloidosis in patients on long-term hemodialysis.
Sequence similaritiesBelongs to the beta-2-microglobulin family.
Contains 1 Ig-like C1-type (immunoglobulin-like) domain.
modificationsGlycation of Ile-21 is observed in long-term hemodialysis patients.
Cellular localizationSecreted. Detected in serum and urine.
- Information by UniProt
- B2M antibody
- B2MG_HUMAN antibody
- Beta 2 microglobin antibody
This product has been referenced in:
- Kotsiou E et al. Dimerization of soluble disulfide trap single-chain major histocompatibility complex class I molecules dependent on Peptide binding affinity. Antioxid Redox Signal 15:635-44 (2011). WB ; Human . Read more (PubMed: 21050141) »
- Vecchi C et al. Huh-7: a human "hemochromatotic" cell line. Hepatology 51:654-9 (2010). ICC/IF ; Human . Read more (PubMed: 20017200) »