Anti-beta 3 Adrenergic Receptor antibody - N-terminal (ab140713)
Key features and details
- Rabbit polyclonal to beta 3 Adrenergic Receptor - N-terminal
- Suitable for: IHC-P
- Reacts with: Human
- Isotype: IgG
Overview
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Product name
Anti-beta 3 Adrenergic Receptor antibody - N-terminal
See all beta 3 Adrenergic Receptor primary antibodies -
Description
Rabbit polyclonal to beta 3 Adrenergic Receptor - N-terminal -
Host species
Rabbit -
Tested applications
Suitable for: IHC-Pmore details -
Species reactivity
Reacts with: Human
Predicted to work with: Rabbit, Guinea pig, Monkey, Gorilla, Elephant -
Immunogen
Synthetic peptide, corresponding to a 20 residue sequence within N terminal (extracellular domain) amino acids of Human beta 3 Adrenergic Receptor (NP_000016.1).
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Positive control
- Human adipose tissue
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General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. -
Storage buffer
Preservative: 0.1% Sodium azide
Constituent: 99% PBS -
Concentration information loading...
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Purity
Immunogen affinity purified -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab140713 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
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IHC-P |
Use a concentration of 17 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.
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Notes |
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IHC-P
Use a concentration of 17 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol. |
Target
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Function
Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. Beta-3 is involved in the regulation of lipolysis and thermogenesis. -
Tissue specificity
Expressed mainly in adipose tissues. -
Sequence similarities
Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRB3 sub-subfamily. -
Cellular localization
Cell membrane. - Information by UniProt
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Database links
- Entrez Gene: 100135478 Guinea pig
- Entrez Gene: 155 Human
- Omim: 109691 Human
- SwissProt: P13945 Human
- Unigene: 2549 Human
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Alternative names
- ADR B3 antibody
- ADRB 3 antibody
- ADRB3 antibody
see all
Images
Datasheets and documents
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SDS download
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Datasheet download
References (3)
ab140713 has been referenced in 3 publications.
- Bruno G et al. ß3-adrenoreceptor blockade reduces tumor growth and increases neuronal differentiation in neuroblastoma via SK2/S1P2 modulation. Oncogene 39:368-384 (2020). PubMed: 31477835
- Calvani M et al. ß3-Adrenoreceptor Blockade Reduces Hypoxic Myeloid Leukemic Cells Survival and Chemoresistance. Int J Mol Sci 21:N/A (2020). PubMed: 32545695
- Deng J et al. Targeting ß3-adrenergic receptor signaling inhibits neuroblastoma cell growth via suppressing the mTOR pathway. Biochem Biophys Res Commun 514:295-300 (2019). PubMed: 31030945