- References (9)
Product namebeta-Amyloid Peptide (1-42) (human)
Descriptionbeta-Amyloid (1-42) protein fragment. Implicated in Alzheimer's disease.
42-Residue amyloid beta-protein fragment; the predominant form of amyloid beta found in the brains of people with Alzheimer's disease and Down's syndrome. Neurotoxic. Shown to induce neuronal death via actions at the p75 neurotrophin receptor.
Storage instructionsStore at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
This product is supplied in one (or more) pack size which is freeze dried. Therefore the contents may not be readily visible, as they can coat the bottom or walls of the vial. Please see our FAQs and information page for more details on handling.
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one week. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
This product has been referenced in:
- Sotthibundhu A et al. Beta-amyloid(1-42) induces neuronal death through the p75 neurotrophin receptor. J Neurosci 28:3941-6 (2008). Read more (PubMed: 18400893) »
- Nagele RG et al. Intracellular accumulation of beta-amyloid(1-42) in neurons is facilitated by the alpha 7 nicotinic acetylcholine receptor in Alzheimer's disease. Neuroscience 110:199-211 (2002). Read more (PubMed: 11958863) »
- Roher AE et al. beta-Amyloid-(1-42) is a major component of cerebrovascular amyloid deposits: implications for the pathology of Alzheimer disease. Proc Natl Acad Sci U S A 90:10836-40 (1993). Read more (PubMed: 8248178) »
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