Anti-beta Actin antibody (ab119716)

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Overview

  • Product name

    Anti-beta Actin antibody
    See all beta Actin primary antibodies

  • Description

    Rabbit polyclonal to beta Actin

  • Host species

    Rabbit

  • Tested applications

    Suitable for: WBmore details

  • Species reactivity

    Reacts with: Mouse, Rat, Human

  • Immunogen

    Synthetic peptide corresponding to amino acids at the C-terminal of Human beta Actin.

  • Positive control

    • HeLa, 293T, PC12 and NIH3T3 cell lysates.

Properties

Applications

Our Abpromise guarantee covers the use of ab119716 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/5000. Predicted molecular weight: 42 kDa.

Target

  • Function

    Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.

  • Involvement in disease

    Defects in ACTB are a cause of dystonia juvenile-onset (DYTJ) [MIM:607371]. DYTJ is a form of dystonia with juvenile onset. Dystonia is defined by the presence of sustained involuntary muscle contraction, often leading to abnormal postures. DYTJ patients manifest progressive, generalized, dopa-unresponsive dystonia, developmental malformations and sensory hearing loss.

  • Sequence similarities

    Belongs to the actin family.

  • Post-translational
    modifications

    ISGylated.

  • Cellular localization

    Cytoplasm > cytoskeleton. Localized in cytoplasmic mRNP granules containing untranslated mRNAs.
  • Information by UniProt

  • Database links

    see all

  • Alternative names

    • A26C1A antibody
    • A26C1B antibody
    • ACTB antibody
    • ACTB_HUMAN antibody
    • Actin beta antibody
    • Actin cytoplasmic 1 antibody
    • Actin, cytoplasmic 1, N-terminally processed antibody
    • Actx antibody
    • b actin antibody
    • b-actin antibody
    • Beta cytoskeletal actin antibody
    • Beta-actin antibody
    • BRWS1 antibody
    • E430023M04Rik antibody
    • Melanoma X actin antibody
    • MGC128179 antibody
    • PS1TP5 binding protein 1 antibody
    • PS1TP5BP1 antibody
    see all

Images

  • Western blot - Anti-beta Actin antibody (ab119716)
    Western blot - Anti-beta Actin antibody (ab119716)
    All lanes : Anti-beta Actin antibody (ab119716) at 1/5000 dilution

    Lane 1 : HeLa cell lysate
    Lane 2 : 293T cell lysate
    Lane 3 : PC12 cell lysate
    Lane 4 : NIH3T3 cell lysate

    Predicted band size: 42 kDa

References

This product has been referenced in:

  • Cardenas EI  et al. Munc18-2, but not Munc18-1 or Munc18-3, regulates platelet exocytosis, hemostasis, and thrombosis. J Biol Chem 294:4784-4792 (2019). Read more (PubMed: 30696774) »
  • Fang Z  et al. miR-381 and miR-489 suppress cell proliferation and invasion by targeting CUL4B via the Wnt/ß-catenin pathway in gastric cancer. Int J Oncol 54:733-743 (2019). Read more (PubMed: 30483755) »
See all 20 Publications for this product

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