Overview

  • Product name
    Anti-beta Actin antibody
    See all beta Actin primary antibodies
  • Description
    Rabbit polyclonal to beta Actin
  • Host species
    Rabbit
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Mouse, Rat, Human
  • Immunogen

    Synthetic peptide corresponding to amino acids at the C-terminal of Human beta Actin.

  • Positive control
    • HeLa, 293T, PC12 and NIH3T3 cell lysates.

Properties

Applications

Our Abpromise guarantee covers the use of ab119716 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/5000. Predicted molecular weight: 42 kDa.

Target

  • Function
    Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.
  • Involvement in disease
    Defects in ACTB are a cause of dystonia juvenile-onset (DYTJ) [MIM:607371]. DYTJ is a form of dystonia with juvenile onset. Dystonia is defined by the presence of sustained involuntary muscle contraction, often leading to abnormal postures. DYTJ patients manifest progressive, generalized, dopa-unresponsive dystonia, developmental malformations and sensory hearing loss.
  • Sequence similarities
    Belongs to the actin family.
  • Post-translational
    modifications
    ISGylated.
  • Cellular localization
    Cytoplasm > cytoskeleton. Localized in cytoplasmic mRNP granules containing untranslated mRNAs.
  • Information by UniProt
  • Database links
    see all
  • Alternative names
    • A26C1A antibody
    • A26C1B antibody
    • ACTB antibody
    • ACTB_HUMAN antibody
    • Actin beta antibody
    • Actin cytoplasmic 1 antibody
    • Actin, cytoplasmic 1, N-terminally processed antibody
    • Actx antibody
    • b actin antibody
    • Beta cytoskeletal actin antibody
    • Beta-actin antibody
    • BRWS1 antibody
    • E430023M04Rik antibody
    • MGC128179 antibody
    • PS1TP5 binding protein 1 antibody
    • PS1TP5BP1 antibody
    see all

Images

  • Western blot - Anti-beta Actin antibody (ab119716)
    Western blot - Anti-beta Actin antibody (ab119716)
    All lanes : Anti-beta Actin antibody (ab119716) at 1/5000 dilution

    Lane 1 : HeLa cell lysate
    Lane 2 : 293T cell lysate
    Lane 3 : PC12 cell lysate
    Lane 4 : NIH3T3 cell lysate

    Predicted band size: 42 kDa

References

This product has been referenced in:
  • Park YY  et al. ATP depletion during mitotic arrest induces mitotic slippage and APC/CCdh1-dependent cyclin B1 degradation. Exp Mol Med 50:46 (2018). Read more (PubMed: 29700288) »
  • Ma X  et al. Hippo signaling promotes JNK-dependent cell migration. Proc Natl Acad Sci U S A 114:1934-1939 (2017). Read more (PubMed: 28174264) »

See all 12 Publications for this product

Publishing research using ab119716? Please let us know so that we can cite the reference in this datasheet.

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