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    beta-amyloid-peptide-1-42-human-ab120301.pdf

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Neuroscience Neurology process Neurodegenerative disease Alzheimer's disease Amyloid
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beta-Amyloid Peptide (1-42) (human) (ab120301)

  • Datasheet
  • SDS
  • COA
  • Protocol Booklet
Reviews (1)Q&A (3)References (13)

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Chemical Structure - beta-Amyloid Peptide (1-42) (human) (ab120301)

    Key features and details

    • beta-Amyloid (1-42) protein fragment. Implicated in Alzheimer's disease.
    • CAS Number: 107761-42-2
    • Purity: > 95%
    • Solubility is batch-dependent. Please refer to the Protocol Booklet and the batch-specific CoA for more information.

    • Form / State: Solid
    • Source: Synthetic

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    Overview

    • Product name

      beta-Amyloid Peptide (1-42) (human)
    • Description

      beta-Amyloid (1-42) protein fragment. Implicated in Alzheimer's disease.
    • Alternative names

      • AB42
    • Purity

      > 95%
    • CAS Number

      107761-42-2
    • Chemical structure

      Chemical Structure

    Properties

    • Molecular weight

      4514.08
    • Molecular formula

      C203H311N55O60S
    • Sequence

      DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIA
    • PubChem identifier

      57339251
    • Storage instructions

      Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
    • Solubility overview

      Solubility is batch-dependent. Please refer to the Protocol Booklet and the batch-specific CoA for more information.

    • Handling

      This product is supplied in one (or more) pack size which is freeze dried. Therefore the contents may not be readily visible, as they can coat the bottom or walls of the vial. Please see our FAQs and information page for more details on handling.

      Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one week. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

      Refer to SDS for further information.

      Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

    • Source

      Synthetic

    • Research areas

      • Neuroscience
      • Neurology process
      • Neurodegenerative disease
      • Alzheimer's disease
      • Amyloid
      • Biochemicals
      • Chemical Type
      • Biochemicals
      • Biochemicals
      • Chemical Type
      • Bioactive peptides
      • Biochemicals
      • Pharmacology
      • Signaling
      • Amyloidogenesis
      • Biochemicals
      • Pharmacology
      • Receptors & Transporters
      • Catalytic Receptors
      • Neurotrophins
      • p75
      • Biochemicals
      • Research Area
      • Heart disease
      • Signaling
      • Amyloidogenesis
      • Biochemicals
      • Research Area
      • Pain & inflammation
      • Signaling
      • Amyloidogenesis
      • Biochemicals
      • Research Area
      • Alzheimer's Disease
      • Signaling
      • Amyloidogenesis
      • Biochemicals
      • Research Area
      • Diabetes
      • Signaling
      • Amyloidogenesis
      • Biochemicals
      • Research Area
      • Hypertension
      • Signaling
      • Amyloidogenesis
      • Biochemicals
      • Research Area
      • Obesity
      • Signaling
      • Amyloidogenesis
      • Biochemicals
      • Research Area
      • Respiratory disease
      • Signaling
      • Amyloidogenesis
      • Biochemicals
      • Research Area
      • Stroke
      • Signaling
      • Amyloidogenesis

    Associated products

    • Related Products

      • Anti-beta Amyloid antibody [MOAB-2] (ab126649)
      • Anti-Tau (phospho S238) antibody [12G10] (ab128889)
      • Anti-Serum Amyloid P/SAP antibody [342CT9.4.7] (ab87914)

    Images

    • Chemical Structure - beta-Amyloid Peptide (1-42) (human) (ab120301)
      Chemical Structure - beta-Amyloid Peptide (1-42) (human) (ab120301)
      2D chemical structure image of ab120301, beta-Amyloid Peptide (1-42) (human)

    Protocols

    • Protocol Booklet

    Click here to view the general protocols

    Datasheets and documents

    • SDS download

    • Datasheet download

      Download
    • COA

    References (13)

    Publishing research using ab120301? Please let us know so that we can cite the reference in this datasheet.

    ab120301 has been referenced in 13 publications.

    • Sabouri M  et al. Moderate treadmill exercise improves spatial learning and memory deficits possibly via changing PDE-5, IL-1 ß and pCREB expression. Exp Gerontol 139:111056 (2020). PubMed: 32791334
    • Karthick C  et al. Time-dependent effect of oligomeric amyloid-ß (1-42)-induced hippocampal neurodegeneration in rat model of Alzheimer's disease. Neurol Res 41:139-150 (2019). PubMed: 30453864
    • Qin M  et al. SET SUMOylation promotes its cytoplasmic retention and induces tau pathology and cognitive impairments. Acta Neuropathol Commun 7:21 (2019). PubMed: 30767764
    • Wang Y  et al. Alcohol Dehydrogenase 1B Suppresses ß-Amyloid-Induced Neuron Apoptosis. Front Aging Neurosci 11:135 (2019). PubMed: 31231206
    • Sivaji K  et al. Exogenous human beta amyloid peptide interferes osteogenesis through Sox9a in embryonic zebrafish. Mol Biol Rep 46:4975-4984 (2019). PubMed: 31264162
    View all Publications for this product

    Customer reviews and Q&As

    Show All Reviews Q&A
    Submit a review

    Filter by Ratings

    Attempt to locate Amyloid beta in nasal mucosa

    Excellent
    Abreviews
    Abreviews
    abreview image
    ab120301 worked very well as a comparison in our dot blot experiment attempting to locate amyloid beta in the nasal mucous of humans. As seen in the depiction it clearly appeared as expected after dilution and when using it to spike certain samples. The product manual and data sheet were both accurate and very easy to follow and allowed us to more easily conduct the experiment.

    Abcam user community

    Verified customer

    Submitted Mar 20 2019

    Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
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