Overview

  • Product name

    beta-Amyloid peptide (16-22)
  • Description

    Amyloidogenic peptide forming an antiparallel beta-sheet. beta-Amyloid peptide (16-22).
  • Biological description

    Amyloidogenic peptide forming an antiparallel beta-sheet. A 7 residue section of the parent beta-peptide (42 residues) from Alzheimer's amyloid precursor protein. Comprises the central hydrophobic core thought to be important in amyloid beta formation. Region contains four Alzheimer's disease causing mutation sites.

  • Purity

    > 95%
  • Chemical structure

    Chemical Structure

Properties

  • Molecular weight

    853.03
  • Molecular formula

    C43H65N8O10
  • Sequence

    KLVFFAE
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in water to 1 mg/ml
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Santini S  et al. Pathway complexity of Alzheimer's beta-amyloid Abeta16-22 peptide assembly. Structure 12:1245-55 (2004). Read more (PubMed: 15242601) »
  • Favrin G  et al. Oligomerization of amyloid Abeta16-22 peptides using hydrogen bonds and hydrophobicity forces. Biophys J 87:3657-64 (2004). Read more (PubMed: 15377534) »
  • Ma B & Nussinov R Stabilities and conformations of Alzheimer's beta -amyloid peptide oligomers (Abeta 16-22, Abeta 16-35, and Abeta 10-35): Sequence effects. Proc Natl Acad Sci U S A 99:14126-31 (2002). Read more (PubMed: 12391326) »
See 1 Publication for this product

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