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    beta-endorphin-antibody-ab10339.pdf

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Neuroscience Neurotransmitter Neuropeptides Opioids
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Anti-beta Endorphin antibody (ab10339)

  • Datasheet
  • SDS
Submit a review Q&A (1)References (1)

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Key features and details

  • Rabbit polyclonal to beta Endorphin
  • Reacts with: Mouse, Rat, Human
  • Isotype: IgG

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Overview

  • Product name

    Anti-beta Endorphin antibody
    See all beta Endorphin primary antibodies
  • Description

    Rabbit polyclonal to beta Endorphin
  • Host species

    Rabbit
  • Species reactivity

    Reacts with: Mouse, Rat, Human
  • Immunogen

    Antiserum to beta Endorphin was raised in rabbits by using the N-terminal portion of bovine beta Endorphin conjugated to thyroglobulin.

    Run BLAST with BLAST the sequence with ExPASy Run BLAST with BLAST the sequence with NCBI
  • General notes

    The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing the problem with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation.

    One factor contributing to the crisis is the use of antibodies that are not suitable. This can lead to misleading results and the use of incorrect data informing project assumptions and direction. To help address this challenge, we have introduced an application and species grid on our primary antibody datasheets to make it easy to simplify identification of the right antibody for your needs.

    Learn more here.

Properties

  • Form

    Liquid
  • Storage instructions

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • Storage buffer

    Preservative: 0.1% Sodium azide
  • Concentration information loading...
  • Purity

    Whole antiserum
  • Clonality

    Polyclonal
  • Isotype

    IgG
  • Research areas

    • Neuroscience
    • Neurotransmitter
    • Neuropeptides
    • Opioids
    • Neuroscience
    • Neurotransmitter
    • Neuropeptides
    • Hormones
    • Signal Transduction
    • Growth Factors/Hormones
    • Hormones
    • Neuroscience
    • Endocrine system
    • Hypothalamic pituitary adrenal axis
    • Cancer
    • Tumor biomarkers
    • Hormones
    • Cancer
    • Cancer Metabolism
    • Metabolic signaling pathway
    • Hormone biosynthesis
    • Metabolism
    • Pathways and Processes
    • Endocrine metabolism
    • Hormone biosynthesis
    • Metabolism
    • Types of disease
    • Cancer

Associated products

  • Compatible Secondaries

    • Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (ab150077)
    • Goat Anti-Rabbit IgG H&L (HRP) (ab205718)
  • Isotype control

    • Rabbit IgG, polyclonal - Isotype Control (ChIP Grade) (ab171870)

Target

  • Relevance

    Beta-endorphin is an endogenous opioid peptide neurotransmitter found in the neurons of both the central and peripheral nervous system. ß-endorphin is a peptide, 31 amino acids long, resulting from processing of the precursor pro-opiomelanocortin (POMC). ß-endorphin is found in neurons of the hypothalamus as well as the pituitary gland. It is an agonist of the opioid receptors, with evidence suggesting that it serves as the endogenous ligand of the µ-opioid receptor, the same receptor to which the chemicals extracted from opium, such as morphine and codeine, have their analgesic and addictive effects
  • Cellular localization

    Secreted
  • Database links

    • Entrez Gene: 5443 Human
    • Entrez Gene: 18976 Mouse
    • Entrez Gene: 24664 Rat
    • Omim: 176830 Human
    • SwissProt: P01189 Human
    • SwissProt: P01193 Mouse
    • SwissProt: P01194 Rat
    • Unigene: 1897 Human
    • Alternative names

      • Beta endorphin antibody
      • Corticotropin lipotropin antibody
      • POMC antibody
      • Proopiomelanocortin antibody

    Protocols

    • Immunocytochemistry & immunofluorescence protocols

    Click here to view the general protocols

    Datasheets and documents

    • SDS download

    • Datasheet download

      Download

    References (1)

    Publishing research using ab10339? Please let us know so that we can cite the reference in this datasheet.

    ab10339 has been referenced in 1 publication.

    • Shi MM  et al. Hippocampal µ-opioid receptors on GABAergic neurons mediate stress-induced impairment of memory retrieval. Mol Psychiatry 25:977-992 (2020). PubMed: 31142818

    Customer reviews and Q&As

    Show All Reviews Q&A
    Submit a review Submit a question

    Question

    I am interested in two antibodies. Beta endorphin antibody (ab10339) and Beta endorphin antibody (ab8907). Before I purchase one of these, I would like to know what is the immunogen for each one. On the website, it is not specific enough. Thank you for your help.

    Read More

    Abcam community

    Verified customer

    Asked on May 17 2004

    Answer

    Thank you for your patience. Regarding ab10339, antiserum to beta-endorphin was raised in rabbits by using synthetic human beta-endorphin (H-Tyr-Gly-Gly-Phe-Met-Thr-Ser-Lys-Ser-Gln-Thr-Pro-Leu-Val-Thr-Leu-Phe-Lys-Asn-Ala-Ile-Ile-Lys-Asn-Ala-Tyr-Lys-Lys-Gly-Glu-OH) conjugated to thyroglobulin. Once I hear back regarding ab8907, I will contact you again.

    Read More

    Abcam Scientific Support

    Answered on May 19 2004

    Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES"
    For licensing inquiries, please contact partnerships@abcam.com

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