Anti-beta Endorphin antibody [B 31.15] (ab54205)
Key features and details
- Mouse monoclonal [B 31.15] to beta Endorphin
- Suitable for: IHC-Fr, IHC-P
- Reacts with: Rat, Human, Macaque monkey
- Isotype: IgG1
Overview
-
Product name
Anti-beta Endorphin antibody [B 31.15] -
Description
Mouse monoclonal [B 31.15] to beta Endorphin -
Host species
Mouse -
Tested applications
Suitable for: IHC-Fr, IHC-Pmore details -
Species reactivity
Reacts with: Rat, Human, Macaque monkey -
Immunogen
Full length native human beta Endorphin.
-
General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
-
Form
Liquid -
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles. -
Storage buffer
pH: 7.20
Preservative: 0.1% Sodium azide
Constituent: PBS -
Concentration information loading...
-
Purity
Protein A purified -
Clonality
Monoclonal -
Clone number
B 31.15 -
Isotype
IgG1 -
Research areas
Associated products
-
Compatible Secondaries
-
Isotype control
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab54205 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
---|---|---|
IHC-Fr |
Use at an assay dependent concentration.
|
|
IHC-P |
Use at an assay dependent concentration.
|
Notes |
---|
IHC-Fr
Use at an assay dependent concentration. |
IHC-P
Use at an assay dependent concentration. |
Target
-
Relevance
Beta-endorphin is an endogenous opioid peptide neurotransmitter found in the neurons of both the central and peripheral nervous system. ß-endorphin is a peptide, 31 amino acids long, resulting from processing of the precursor pro-opiomelanocortin (POMC). ß-endorphin is found in neurons of the hypothalamus as well as the pituitary gland. It is an agonist of the opioid receptors, with evidence suggesting that it serves as the endogenous ligand of the µ-opioid receptor, the same receptor to which the chemicals extracted from opium, such as morphine and codeine, have their analgesic and addictive effects -
Cellular localization
Secreted -
Database links
- Entrez Gene: 5443 Human
- Entrez Gene: 24664 Rat
- Omim: 176830 Human
- SwissProt: P01189 Human
- SwissProt: P01194 Rat
-
Alternative names
- Beta endorphin antibody
- Corticotropin lipotropin antibody
- POMC antibody
- Proopiomelanocortin antibody
Protocols
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
Datasheets and documents
-
SDS download
-
Datasheet download
References (4)
ab54205 has been referenced in 4 publications.
- Lau BK et al. Mu-Opioids Suppress GABAergic Synaptic Transmission onto Orbitofrontal Cortex Pyramidal Neurons with Subregional Selectivity. J Neurosci 40:5894-5907 (2020). PubMed: 32601247
- Dees WL et al. Regulation of prepubertal dynorphin secretion in the medial basal hypothalamus of the female rat. J Neuroendocrinol 31:e12810 (2019). PubMed: 31715027
- Ranganathan S et al. Molecular interpretation of ACTH-ß-endorphin coaggregation: relevance to secretory granule biogenesis. PLoS One 7:e31924 (2012). IHC-Fr ; Rat . PubMed: 22403619
- Ubuka T et al. Gonadotropin-inhibitory hormone identification, cDNA cloning, and distribution in rhesus macaque brain. J Comp Neurol 517:841-55 (2009). ICC/IF ; Macaque monkey . PubMed: 19844991