beta-Rubromycin, HIV-1 reverse transcriptase inhibitor (ab144349)

Overview

  • Product name

    beta-Rubromycin, HIV-1 reverse transcriptase inhibitor
  • Description

    Antibiotic agent. Selective, reversible HIV-1 reverse transcriptase inhibitor. Telomerase inhibitor.
  • Biological description

    Antibiotic agent. Selective, reversible HIV-1 reverse transcriptase inhibitor. Shows equipotent template-primer competitive, TTP non-competitive RT inhibition as γ-rubromycin (ab144350). Telomerase inhibitor (IC50 = 1.3 μM, human telomerase). Shows antibacterial and cytostatic effects.
  • Purity

    > 98%
  • CAS Number

    27267-70-5
  • Chemical structure

    Chemical Structure

Properties

References

This product has been referenced in:

  • Mizushina Y  et al. Anti-cancer targeting telomerase inhibitors: ß-rubromycin and oleic acid. Mini Rev Med Chem 12:1135-43 (2012). Read more (PubMed: 22876944) »
  • Ueno T  et al. Inhibition of human telomerase by rubromycins: implication of spiroketal system of the compounds as an active moiety. Biochemistry 39:5995-6002 (2000). Read more (PubMed: 10821671) »
  • Goldman ME  et al. Inhibition of human immunodeficiency virus-1 reverse transcriptase activity by rubromycins: competitive interaction at the template.primer site. Mol Pharmacol 38:20-5 (1990). Read more (PubMed: 1695317) »

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